Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.
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DOI: 10.1021/jacs.7b13703
Abstract: Small GTPases (sGTPases) are critical switch-like regulators that mediate several important cellular functions and are often mutated in human cancers. They are activated by guanine nucleotide exchange factors (GEFs), which specifically catalyze the exchange of… read more here.
Keywords: guanine nucleotide; nucleotide exchange; real time; time nmr ... See more keywords