Residence Times for Femtomolar and Picomolar Inhibitors of MTANs.
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DOI: 10.1021/acs.biochem.3c00145
Abstract: 5'-Methylthioadenosine nucleosidases (MTANs) catalyze the hydrolysis of 5'-substituted adenosines to form adenine and 5-substituted ribose. Escherichia coli MTAN (EcMTAN) and Helicobacter pylori MTAN (HpMTAN) form late and early transition states, respectively. Transition state analogues designed… read more here.
Keywords: transition state; dissociation; residence times; times femtomolar ... See more keywords