Repurposing Ophthalmologic Timolol for Dermatologic Use: Caveats and Historical Review of Adverse Events
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Clinical Dermatology"
DOI: 10.1007/s40257-020-00567-3
Abstract: Ophthalmic timolol solution is increasingly being repurposed as a topical therapeutic for a variety of dermatologic diseases, including pyogenic granulomas, infantile hemangiomas, and chronic wounds. There are no published guidelines or protocols for use in… read more here.
Keywords: timolol; dermatologic use; review; adverse events ... See more keywords
Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2).
Sign Up to like & getrecommendations! Published in 2018 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2017.11.019
Abstract: PURPOSE To evaluate the efficacy and ocular and systemic safety of netarsudil 0.02% ophthalmic solution, a rho-kinase inhibitor and norepinephrine transporter inhibitor, in patients with open-angle glaucoma and ocular hypertension. DESIGN Double-masked, randomized noninferiority clinical… read more here.
Keywords: timolol; treatment; clinical trials; rocket ... See more keywords
Omega‐3 fatty acids protect retinal neurons in the DBA/2J hereditary glaucoma mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.12.005
Abstract: Abstract The purpose of this study was to evaluate the neuroprotective effects of omega‐3 polyunsaturated fatty acid (ω3‐PUFA) supplementation, alone or in combination with timolol eye drops, in a mouse model of hereditary glaucoma. DBA/2J… read more here.
Keywords: pufa; timolol; hereditary glaucoma; pufas ... See more keywords
Co-delivery of timolol and hyaluronic acid from semi-circular ring-implanted contact lenses for the treatment of glaucoma: in vitro and in vivo evaluation.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials science"
DOI: 10.1039/c8bm00212f
Abstract: Glaucoma is a chronic disease, which is currently treated using frequent high dose applications of an eye drop solution; this method is tedious, and most of patients are non-compliant to it. Contact lenses are emerging… read more here.
Keywords: timolol; timolol hyaluronic; hyaluronic acid; contact lenses ... See more keywords
Timolol loaded microemulsion laden silicone contact lens to manage glaucoma: in vitro and in vivo studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Dispersion Science and Technology"
DOI: 10.1080/01932691.2019.1710183
Abstract: Abstract To manage glaucoma, timolol is currently delivered via eye drop solution in high doses due to poor ocular bioavailability. The silicone contact lenses can be used to control the release of timolol by conventional… read more here.
Keywords: timolol; microemulsion; solution; contact ... See more keywords
A randomized clinical trial comparing three fixed combinations of bimatoprost with timolol in patients with open-angle glaucoma or ocular hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2023.2197496
Abstract: Abstract Objective To compare the efficacy and safety of two fixed combination, preservative-free eye drops (bimatoprost 0.01% in combination with either timolol 0.1% or 0.5%) in a gel formulation, with bimatoprost 0.03%/timolol 0.5% in patients… read more here.
Keywords: bimatoprost timolol; timolol patients; patients open; open angle ... See more keywords
Reviewing the evidence surrounding preservative-free tafluprost/timolol fixed-dose combination therapy in open-angle glaucoma and ocular hypertension management: a focus on efficacy, safety, and tolerability
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2022.2135701
Abstract: ABSTRACT Introduction Elevated intraocular pressure (IOP) is the most important modifiable risk factor for irreversible sight loss in open-angle glaucoma (OAG). The topical fixed-dose combination (FC) of preservative-free (PF) tafluprost (0.0015%) and timolol (0.5%) (tafluprost/timolol)… read more here.
Keywords: glaucoma; tolerability; therapy; tafluprost timolol ... See more keywords
Ophthalmic Timolol Hallucinations: A Case Series and Review of the Literature
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DOI: 10.1097/ijg.0000000000000712
Abstract: Purpose: Systemic absorption and central nervous system (CNS) penetration of timolol drops are a well-studied phenomenon, resulting in common side effects such as bradycardia, bronchospasm, fatigue, and confusion. More serious CNS side effects, such as… read more here.
Keywords: timolol; series review; case series; pathology ... See more keywords
Effects of Brimonidine and Timolol on the Progression of Visual Field Defects in Open-angle Glaucoma: A Single-center Randomized Trial
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Glaucoma"
DOI: 10.1097/ijg.0000000000001285
Abstract: Supplemental Digital Content is available in the text. Précis: Instillation of brimonidine or timolol slowed visual field deterioration in patients with open-angle glaucoma; both brimonidine and timolol might improve the mean deviation (MD) slopes. Purpose:… read more here.
Keywords: visual field; brimonidine timolol; timolol; angle glaucoma ... See more keywords
The effect of Timolol 0.5% on the correction of myopic regression after LASIK
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DOI: 10.1097/md.0000000000006782
Abstract: Backgroud: Postlaser in situ keratomileusis (post-LASIK) refractive regression is defined as the gradual, partial, or total loss of initial correction that limits the predictability, efficiency, and long-term stability of LASIK. Our study assesses the effect… read more here.
Keywords: regression; timolol; myopic regression; treatment ... See more keywords
Efficacy and safety of topical timolol 0.5% plus saline 0.9% versus each one alone in acne scar trichloroacetic acid‐CROSS therapy: A blinded randomized controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "Dermatologic Therapy"
DOI: 10.1111/dth.15341
Abstract: Trichloroacetic acid‐CROSS (TCA‐CROSS) or chemical reconstruction of scars is an approved method in the treatment of ICE‐PICK scars. Timolol is a blocker of beta‐adrenergic receptors that speeds up the healing of skin wounds. In this… read more here.
Keywords: side; group; cross; treatment ... See more keywords