Biopharmaceutics and Pharmacokinetics of Timosaponin A-III by a Sensitive HPLC-MS/MS Method: Low Bioavailability Resulting from Poor Permeability and Solubility.
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DOI: 10.2174/1389201021666200707134045
Abstract: BACKGROUND Timosaponin A-III is one of the most promising active saponins from Anemarrhena asphodeloides Bge. As an oral chemotherapeutic agent, there is an urgent need to clarify its biopharmaceutics and pharmacokinetics to improve its development… read more here.
Keywords: timosaponin; timosaponin iii; bioavailability; permeability ... See more keywords