Timosaponin AIII induces apoptosis and autophagy in human melanoma A375-S2 cells
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DOI: 10.1007/s12272-016-0763-3
Abstract: Timosaponin AIII (AIII), a steroidal saponin isolated from Anemarrhena asphodeloides Bge. Our study showed that AIII induced both apoptosis and autophagy, and autophagy inhibited apoptosis in A375S2 cells. Furtherly, this study was carried out to… read more here.
Keywords: apoptosis autophagy; timosaponin aiii; aiii induces; autophagy human ... See more keywords
Timosaponin AIII Suppresses RAP1 Signaling Pathway to Enhance the Inhibitory Effect of Paclitaxel on Nasopharyngeal Carcinoma
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DOI: 10.1155/2022/6756676
Abstract: Although PTX has been identified as an effective drug for nasopharyngeal carcinoma (NPC) therapy, it has serious side effects in the human body. Previous studies have shown that timosaponin AIII (TSAIII) can inhibit the malignant… read more here.
Keywords: nasopharyngeal carcinoma; inhibitory effect; effect; ptx ... See more keywords
Pharmacological Activity, Pharmacokinetics, and Toxicity of Timosaponin AIII, a Natural Product Isolated From Anemarrhena asphodeloides Bunge: A Review
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DOI: 10.3389/fphar.2020.00764
Abstract: Anemarrhena asphodeloides Bunge is a famous Chinese Materia Medica and has been used in traditional Chinese medicine for more than two thousand years. Steroidal saponins are important active components isolated from A. asphodeloides Bunge. Among… read more here.
Keywords: aiii; pharmacokinetics toxicity; asphodeloides bunge; timosaponin aiii ... See more keywords
Functional Axis of PDE5/cGMP Mediates Timosaponin-AIII-Elicited Growth Suppression of Glioblastoma U87MG Cells
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DOI: 10.3390/molecules28093795
Abstract: Glioblastoma (GBM) is the most aggressive brain tumor, with high mortality. Timosaponin AIII (TIA), a steroidal saponin isolated from the medicinal plant Anemarrhena asphodeloides Bge., has been shown to possess anticancer properties in various cancer… read more here.
Keywords: pde5; growth; cgmp; cell growth ... See more keywords