Thermodynamic profiles of the interactions of suramin, chondroitin sulfate, and pentosan polysulfate with the inhibitory domain of TIMP‐3
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13556
Abstract: Extracellular levels of soluble TIMP‐3 are low, reflecting its binding by extracellular matrix (ECM) components including sulfated glycosaminoglycans (SGAGs) and endocytosis via low density lipoprotein receptor‐related protein 1. Since TIMP‐3 inhibits ECM degradation, the ability… read more here.
Keywords: domain timp; chondroitin sulfate; timp; sulfate pentosan ... See more keywords
The invariant chain CD74 protein is a cell surface binding partner of TIMP-1 in breast cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13436
Abstract: Tissue inhibitor of metalloproteinases-1 (TIMP-1) regulates the proteolytic activity of matrix metalloproteinases (MMPs), playing an important role in the homeostasis of the extracellular matrix. Beyond its well-known role in tissue maintenance, TIMP-1 has been associated… read more here.
Keywords: cell surface; breast cancer; timp; cancer cells ... See more keywords
Comparative Study of Cytokine Levels in Different Respiratory Samples in Mild-to-Moderate AECOPD Patients
Sign Up to like & getrecommendations! Published in 2019 at "Lung"
DOI: 10.1007/s00408-019-00263-y
Abstract: Matrix metalloproteinase-12 (MMP-12) and Tissue inhibitor of metalloproteinase-4 (TIMP-4) play important roles in the pathophysiology of chronic obstructive pulmonary disease (COPD). Subjects of many previous studies were patients with severe and very severe COPD. However,… read more here.
Keywords: aecopd; different respiratory; aecopd patients; timp ... See more keywords
Influence of clodronate and compressive force on IL-1ß-stimulated human periodontal ligament fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-019-02930-z
Abstract: Objectives The aim of this study was to investigate in vitro the effect of clodronate on interleukin-1ß (IL-1ß)–stimulated human periodontal ligament fibroblasts (HPdLFs) with the focus on inflammatory factors of orthodontic tooth movement with and… read more here.
Keywords: fold compared; compressive force; timp; force ... See more keywords
Impact of serum HER2, TIMP-1, and CAIX on outcome for HER2+ metastatic breast cancer patients: CCTG MA.31 (lapatinib vs. trastuzumab)
Sign Up to like & getrecommendations! Published in 2017 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-017-4273-x
Abstract: BackgroundThe lapatinib–taxane combination led to shorter PFS than trastuzumab–taxane in HER2+ metastatic breast cancer. We investigated the prognostic and predictive effects of pretreatment serum HER2, CAIX, and TIMP-1.MethodsMA.31 accrued 652 patients; 537 (82%) were centrally confirmed… read more here.
Keywords: serum her2; pfs; her2; timp ... See more keywords
Vascular endothelial growth factor (VEGF), tissue inhibitors of metalloproteinase-1 (TIMP-1) and nail fold capillaroscopy changes in children and adolescents with Gaucher disease; relation to residual disease severity.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155120
Abstract: BACKGROUND Gaucher disease (GD) is caused by functional defects of the acid β-glucocerebrosidase enzyme, with accumulation of glucosylceramide in the macrophage lineage lysosomes causing multisystem abnormalities. However, some GD manifestations can't be explained by Gaucher-cells… read more here.
Keywords: vegf; gaucher disease; disease; timp ... See more keywords
TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
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DOI: 10.1038/s41598-017-00671-1
Abstract: Tissue inhibitor of metalloproteinases-1 (TIMP-1) is upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver by inhibition of matrix metalloproteases (MMP) and degradation of extracellular matrix. Moreover, TIMP-1 displays anti-apoptotic properties,… read more here.
Keywords: fibrogenesis carcinogenesis; fibrogenesis; hepatic fibrogenesis; timp ... See more keywords
TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69008-9
Abstract: Matrix metalloproteinases (MMPs) and the related families of disintegrin metalloproteinases (ADAMs) and ADAMs with thrombospondin repeats (ADAMTSs) play a crucial role in extracellular matrix (ECM) turnover and shedding of cell-surface molecules. The proteolytic activity of… read more here.
Keywords: target metalloproteinases; affinity; timp; receptor ... See more keywords
Structural characterisation of inhibitory and non-inhibitory MMP-9–TIMP-1 complexes and implications for regulatory mechanisms of MMP-9
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92881-x
Abstract: MMP-9 plays a number of important physiological functions but is also responsible for many pathological processes, including cancer invasion, metastasis, and angiogenesis. It is, therefore, crucial to understand its enzymatic activity, including activation and inhibition… read more here.
Keywords: inhibitory mmp; mmp; timp; inhibitory ... See more keywords
Is (TIMP-2)X(IGFBP7) an early renal biomarker for the prediction of acute kidney injury in aortic surgery? – Results from a single center observational study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiothoracic and Vascular Anesthesia"
DOI: 10.1053/j.jvca.2020.09.006
Abstract: Introduction Postoperative acute kidney injury (pAKI) is a typical complication after abdominal aortic repair (AAR) (1). Urinary insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2) were shown to predict pAKI with… read more here.
Keywords: kidney injury; surgery; timp; acute kidney ... See more keywords
TIMP-1 Mediates Inflammatory and Immune Response to IL-6 in Adult Orbital Xanthogranulomatous Disease
Sign Up to like & getrecommendations! Published in 2019 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2019.1581227
Abstract: Abstract Purpose: To explore the pathogenesis that TIMP-1 mediated in adult orbital xanthogranulomatous disease (AOXGD), a rare type of non-Langerhans histiocytosis that damages the appearance and quality of life of patients Methods: We reviewed 22… read more here.
Keywords: timp; adult orbital; orbital xanthogranulomatous; xanthogranulomatous disease ... See more keywords