The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0492-8
Abstract: Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods to… read more here.
Keywords: chronic neuropathic; diagnosis; translational biomarkers; neuropathic pain ... See more keywords
The relationship between primary sarcopenia and SARC-F, serum MMP9, TIMP1 levels, and MMP9/TIMP1 ratio in the geriatric patients
Sign Up to like & getrecommendations! Published in 2021 at "European Geriatric Medicine"
DOI: 10.1007/s41999-021-00519-y
Abstract: The aim of this study was to determine the relationship between primary sarcopenia and SARC-F score, serum MMP9 (Matrix metalloproteinase), TIMP1 (Tissue inhibitor of metalloproteinase) levels, and MMP9/TIMP1 ratio in the geriatric patients. The SARC-F… read more here.
Keywords: sarcopenia; timp1 ratio; mmp9 timp1; timp1 ... See more keywords
The inhibitory effect of M2 macrophage-derived exosomes on gefitinib resistant lung adenocarcinoma cells through the MIF/TIMP1/CD74 axis
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-13948-7
Abstract: Lung adenocarcinoma (LA) ranks among the most common malignant tumors worldwide. M2 macrophage-derived exosomes have been implicated in regulating LA progression and drug resistance. However, whether proteins encapsulated in these exosomes contribute to gefitinib resistance… read more here.
Keywords: macrophage derived; timp1; derived exosomes; macrophage ... See more keywords
TIMP1 promotes cell proliferation and invasion capability of right‐sided colon cancers via the FAK/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15567
Abstract: Although right‐sided colorectal cancer (CRC) shows a worse prognosis than left‐sided CRC, the underlying mechanism remains unclear. We established patient‐derived organoids (PDOs) from left‐ and right‐sided CRCs and directly compared cell proliferation and invasion capability… read more here.
Keywords: pdos; cell proliferation; left sided; right sided ... See more keywords
The Role of Serum CK18, TIMP1, and MMP-9 Levels in Predicting R0 Resection in Patients with Gastric Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Disease Markers"
DOI: 10.1155/2018/5604702
Abstract: Gastric cancer is the third most common cause of death in men and the fifth common cause of death in women worldwide. Currently, available advanced imaging modalities can predict R0 resection in most patients in… read more here.
Keywords: gastric cancer; timp1; serum ck18; mmp ... See more keywords
Abstract 5105: TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5105
Abstract: Brain metastasis is an unmet clinical need, affecting between 10-30% of cancer patients with 200000 to 400000 newly diagnosis per annum in the US. Recently, several clinical trials have reported benefits using immunotherapy to treat… read more here.
Keywords: metastasis; brain; dependent local; timp1 ... See more keywords
Taking a Swing at TIMP1-Armed Immunosuppressive Astrocytes Unleashes T cell Immunity against Brain Metastases.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-24-1495
Abstract: Priego and colleagues identify a secreted glycoprotein TIMP1, expressed downstream of the transcription factor STAT3, in a subpopulation of STAT3+ reactive astrocytes as a mediator of immunosuppression in late-stage brain metastases. The STAT3 inhibitor silibinin… read more here.
Keywords: brain metastases; timp1 armed; timp1; taking swing ... See more keywords
Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63–Integrin &bgr;1 Interaction
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension"
DOI: 10.1161/hypertensionaha.117.09045
Abstract: Myocardial fibrosis is excess accumulation of the extracellular matrix fibrillar collagens. Fibrosis is a key feature of various cardiomyopathies and compromises cardiac systolic and diastolic performance. TIMP1 (tissue inhibitor of metalloproteinase-1) is consistently upregulated in… read more here.
Keywords: timp1; myocardial fibrosis; fibrosis; matrix metalloproteinase ... See more keywords
TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-024-01000-9
Abstract: In clinical practice, alterations in the internal environment of type 2 diabetes can significantly affect bone quality. While the increased risk of fractures among diabetic patients is well-established, the precise mechanisms by which hyperglycemia influences… read more here.
Keywords: type diabetic; timp1; ferroptosis; osteoporosis ... See more keywords
TIMP1 promotes microglia M2 polarization through MAPK pathway to ameliorate early brain injury after ischemia
Sign Up to like & getrecommendations! Published in 2025 at "Hereditas"
DOI: 10.1186/s41065-025-00491-8
Abstract: To explore the molecular regulatory mechanisms and biomarkers in regulating early brain injury (EBI) and inflammatory response after ischemic stroke (IS). Gene expression profiles of GSE148350, GSE35338, and GSE58294 were analyzed to screen the core… read more here.
Keywords: brain; bv2 cells; timp1; injury ... See more keywords
Anti-POSTN and Anti-TIMP1 Autoantibodies as Diagnostic Markers in Esophageal Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.860611
Abstract: Esophageal cancer is one of the most commonly diagnosed malignant gastrointestinal tumors. The aim of the study was to explore the diagnostic values of anti-POSTN and anti-TIMP1 autoantibodies in esophageal squamous cell carcinoma (ESCC). Differentially… read more here.
Keywords: timp1 autoantibodies; timp1; postn anti; anti timp1 ... See more keywords