Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13016
Abstract: MMP‐14 and MMP‐9 are two well‐established cancer targets for which no specific clinically relevant inhibitor is available. Using a powerful combination of computational design and yeast surface display technology, we engineered such an inhibitor starting… read more here.
Keywords: inhibitor; converting broad; mmp; timp2 ... See more keywords
Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00059
Abstract: Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix metalloproteinase (MMP) family of proteins, whose members are key regulators of the proteolysis of extracellular matrix components and hence of multiple biological processes. In… read more here.
Keywords: timp2; mmp; pegylation; chemistry ... See more keywords
EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03362-z
Abstract: Enhancer of zeste homolog 2 (EZH2) is often increased in malignant tumors and is involved in metastasis. EZH2 silences gene expression by tri-methylating the lysine 27 residue of histone H3 (H3K27me3). However, the mechanism underlying… read more here.
Keywords: invasion; h3k27me3; ezh2; ovarian cancer ... See more keywords
Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-54097-y
Abstract: Previous etiologic studies have indicated that both environmental and genetic factors play important roles in the occurrence and development of chronic Achilles tendinopathy (AT). A recent study documented the results of the largest genome-wide association… read more here.
Keywords: mpp7 timp2; timp2 casp8; study; timp2 ... See more keywords
Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2018.1481095
Abstract: Abstract The aim of this case–control study was to assess TIMP2 level in subjects with or without metabolic syndrome (MetS) and to associate levels with non-alcoholic fatty liver changes (NAFLD). Thirty-three MetS subjects and 55… read more here.
Keywords: alcoholic fatty; fatty liver; non alcoholic; metabolic syndrome ... See more keywords
Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25885
Abstract: Developing selective inhibitors for proteolytic enzymes that share high sequence homology and structural similarity is important for achieving high target affinity and functional specificity. Here, we used a combination of yeast surface display and dual-color… read more here.
Keywords: specific inhibitors; mmp9 mmp14; target; mmp14 ... See more keywords
Doxycycline-Induced Changes in Circulating MMP or TIMP2 Levels Are Not Associated with Skeletal-Related Event-Free or Overall Survival in Patients with Bone Metastases from Breast Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15030571
Abstract: Simple Summary The current study was a retrospective exploratory study evaluating whether circulating levels of known targets of doxycycline were altered following administration of doxycycline to bone metastatic breast cancer patients as an indicator of… read more here.
Keywords: skeletal related; survival; doxycycline; timp2 ... See more keywords
[Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and fibroblast activation induced by hypoxia/reoxygenation in rats].
Sign Up to like & getrecommendations! Published in 2023 at "Zhonghua wei zhong bing ji jiu yi xue"
DOI: 10.3760/cma.j.cn121430-20221130-01045
Abstract: OBJECTIVE To explore the role of tropomyosin 3 (TPM3) in hypoxia/reoxygenation (H/R)-induced cardiomyocyte pyroptosis and fibroblast activation. METHODS Rat cardiomyocytes (H9c2 cells) were treated with H/R method to simulate myocardial ischemia/reperfusion (I/R) injury, and cell… read more here.
Keywords: tpm3; pyroptosis; collagen; fibroblast activation ... See more keywords