Dysregulation of microRNA‐181b and TIMP3 is functionally involved in the pathogenesis of diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28536
Abstract: This study aimed to study the roleof microRNA (miR)‐181b and its target TIMP3 in the development of diabetic nephropathy (DMN) via inhibiting the apoptosis of mesangial cells. Real‐time polymerase chain reaction (RT‐PCR) was adopted to… read more here.
Keywords: timp3 mrna; 181b expression; timp3; diabetic nephropathy ... See more keywords
Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2‐dependent TIMP3 m6A modification
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31219
Abstract: Mechanical environment worsening is an important predisposing factor that accelerates intervertebral disc degeneration (IDD), but its specific regulatory mechanisms remain unclear. In this study, we reveal the molecular mechanisms of WTAP/YTHDF2‐mediated m6A modification in abnormal… read more here.
Keywords: abnormal stress; intervertebral disc; timp3; m6a modification ... See more keywords
Glycosaminoglycans influence enzyme activity of MMP2 and MMP2/TIMP3 complex formation - Insights at cellular and molecular level
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41355-2
Abstract: The extracellular matrix (ECM) is a highly dynamic network constantly remodeled by a fine-tuned protein formation and degradation balance. Matrix metalloproteinases (MMPs) constitute key orchestrators of ECM degradation. Their activity is controlled by tissue inhibitors… read more here.
Keywords: timp3 complex; mmp2; formation; timp3 ... See more keywords
Interaction of tissue inhibitor of metalloproteinase 3 gene polymorphism, blood cadmium and total urinary arsenic levels on clear cell renal cell carcinoma
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DOI: 10.1038/s41598-025-94807-3
Abstract: In renal cell carcinoma (RCC), tissue inhibitor of metalloproteinase (TIMP) 3 expression is lost, suggesting that the TIMP3 gene may function as a tumor suppressor gene. Cadmium (Cd) and arsenic (As) exposure may affect the… read more here.
Keywords: timp3; cell; cell rcc; blood ... See more keywords
Absence of significant genetic alterations in the VSX1, SOD1, TIMP3, and LOX genes in Brazilian patients with Keratoconus.
Sign Up to like & getrecommendations! Published in 2021 at "Ophthalmic genetics"
DOI: 10.1080/13816810.2021.1992785
Abstract: PURPOSE To identify inherited or acquired mutations in the VSX1, SOD1, TIMP3 and LOX genes from the combined analysis of corneal and blood samples from patients with Keratoconus. METHODS The casuistry was consisted of samples… read more here.
Keywords: vsx1 sod1; timp3; timp3 lox; sod1 timp3 ... See more keywords
BONE MARROW MESENCHYMAL STEM CELLS INHIBIT THE EFFECT OF TIMP3 BY TRANSMITTING MIR-21-5P, THUS IMPROVING THE ANGIOGENESIS OF RAT ISLETS
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation"
DOI: 10.1097/01.tp.0000701604.70883.e5
Abstract: Purpose: Amounts of islet loss in early post-transplantation periods is a major obstacle to achieving favorable results of islet transplantation. Studies have found that bone marrow mesenchymal stem cells (BMSCs) have a protective effect on… read more here.
Keywords: angiogenesis; islet; effect; timp3 ... See more keywords
Trehalose Protects Keratinocytes against Ultraviolet B Radiation by Activating Autophagy via Regulating TIMP3 and ATG9A
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9366494
Abstract: Trehalose, a natural disaccharide, is synthesized by many organisms when cells are exposed to stressful stimuli. On the basis of its ability to modulate autophagy, trehalose has been considered an innovative drug for ameliorating many… read more here.
Keywords: cell death; timp3; timp3 atg9a; radiation ... See more keywords
Abstract 4647: Potential of TIMP3 regulating the versican status in the colorectal cancer tumor microenvironment
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DOI: 10.1158/1538-7445.am2023-4647
Abstract: Background: In colorectal cancer (CRC), versican (VCAN) accumulation has been found to negatively correlate with CD8+ tumor infiltrating lymphocyte (TIL) abundance and its proteolysis into versikine (Vkine) positively correlates with TIL abundance. TIMP3 has demonstrated… read more here.
Keywords: timp3; vkine; cd8 tils; tumor ... See more keywords
Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis
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DOI: 10.1186/s12943-025-02300-2
Abstract: Hepatocellular carcinoma (HCC) is a major global health concern, necessitating innovative therapeutic strategies. In this study, we investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications. It was… read more here.
Keywords: timp3; rna circdcun1d4; mir 590; hepatocellular carcinoma ... See more keywords
MicroRNA-30d target TIMP3 induces pituitary tumor cell growth and invasion.
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DOI: 10.21037/gs-21-720
Abstract: Background As one of the most common intracranial tumors, pituitary adenomas, especially the Cushing's disease subtype, have been studied for many years. However, at present, effective methods for the early diagnosis of pituitary adenomas are… read more here.
Keywords: expression; timp3; mir 30d; cell ... See more keywords
Overexpression of HOXA-AS2 inhibits inflammation and apoptosis in podocytes via sponging miRNA-302b-3p to upregulate TIMP3.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202005_21187
Abstract: OBJECTIVE To clarify the role of HOXA-AS2 in the progression of diabetic nephropathy (DN) and the molecular mechanism. MATERIALS AND METHODS Relative levels of HOXA-AS2 and microRNA-302b-3p (miRNA-302b-3p) in serum and kidney tissues of DN… read more here.
Keywords: timp3; apoptosis podocytes; mirna 302b; hoxa as2 ... See more keywords