Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex.
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DOI: 10.1038/cr.2017.144
Abstract: Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-TPP1 heterodimer binds to single-stranded telomeric DNAs,… read more here.
Keywords: shelterin complex; tpp1 trf2; tin2;