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   Articles with "tiotropium" as a keyword



Dose Determination for a Fixed-Dose Drug Combination: A Phase II Randomized Controlled Trial for Tiotropium/Olodaterol Versus Tiotropium in Patients with COPD

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recommendations! Published in 2019 at "Advances in Therapy"

DOI: 10.1007/s12325-019-00911-y

Abstract: IntroductionDuring the clinical development of a fixed-dose combination of drugs, it is best practice to conduct dose-finding studies to determine the optimal dose of each component. The aims of this phase II dose-finding study were… read more here.

Keywords: combination; olodaterol; response; tiotropium olodaterol ... See more keywords
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Efficacy of Tiotropium/Olodaterol Compared with Tiotropium as a First-Line Maintenance Treatment in Patients with COPD Who Are Naïve to LAMA, LABA and ICS: Pooled Analysis of Four Clinical Trials

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recommendations! Published in 2020 at "Advances in Therapy"

DOI: 10.1007/s12325-020-01411-0

Abstract: The efficacy of tiotropium/olodaterol compared with tiotropium in patients with chronic obstructive pulmonary disease (COPD) has been demonstrated in a large clinical programme. Currently, randomised controlled trial (RCT) data on dual bronchodilation as first-line maintenance… read more here.

Keywords: tiotropium olodaterol; tiotropium; treatment; maintenance ... See more keywords
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RE-EVALUATION OF THE UPLIFT CLINICAL TRIAL, USING AGE-APPROPRIATE SPIROMETRIC CRITERIA.

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recommendations! Published in 2020 at "Chest"

DOI: 10.1016/j.chest.2020.02.070

Abstract: BACKGROUND The clinical trial of tiotropium in chronic obstructive pulmonary disease (COPD), i.e. UPLIFT, enrolled adults with a mean age of 65 years and moderate-to-severe airflow-obstruction, based on criteria from the Global Initiative for Chronic… read more here.

Keywords: obstruction; airflow obstruction; age; tiotropium ... See more keywords

Tiotropium add-on to inhaled corticosteroids versus addition of long-acting β2-agonists for adults with asthma.

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recommendations! Published in 2018 at "Respiratory medicine"

DOI: 10.1016/j.rmed.2018.08.014

Abstract: Additional management options, and better use of current options, are needed to help support a large proportion of patients with asthma whose symptoms remain uncontrolled on inhaled corticosteroids (ICS). Here, we aim to review the… read more here.

Keywords: addition; long acting; tiotropium; treatment ... See more keywords

Efficacy of tiotropium bromide on spirometric measurements and control of asthma in real life: data from a 1-year clinical follow-up

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recommendations! Published in 2025 at "Journal of Asthma"

DOI: 10.1080/02770903.2025.2499823

Abstract: Abstract Objective Real-life studies are needed to evaluate the clinical outcomes of add-on tiotropium therapy in patients with asthma. The effects of adding tiotropium bromide to the treatment of asthmatic patients on pulmonary functions and… read more here.

Keywords: year; tiotropium bromide; control; tiotropium ... See more keywords

Improving the Efficiency of Randomized Trials: The DYNAGITO Example

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recommendations! Published in 2019 at "COPD: Journal of Chronic Obstructive Pulmonary Disease"

DOI: 10.1080/15412555.2019.1698020

Abstract: Abstract A traditional principle of the randomized controlled trial is that the p-value comparing treatment groups should be computed from the simple crude data. This assumes that the size of the study is sufficiently large… read more here.

Keywords: improving efficiency; tiotropium; example; rate ... See more keywords

Efficacy of budesonide/formoterol and tiotropium combination for the treatment of Chinese patients with chronic obstructive pulmonary disease

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recommendations! Published in 2018 at "Medicine"

DOI: 10.1097/md.0000000000010841

Abstract: Abstract This study investigated the efficacy and safety of budesonide/formoterol (B/F) and tiotropium combination in the management of chronic obstructive pulmonary disease (COPD) in Chinese patients. Between January 2015 and November 2017, 113 eligible Chinese… read more here.

Keywords: tiotropium combination; tiotropium; treatment; efficacy ... See more keywords

Efficacy of tiotropium in treating patients with moderate-to-severe asthma

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recommendations! Published in 2019 at "Medicine"

DOI: 10.1097/md.0000000000016637

Abstract: Abstract Background: The goal of the current meta-analysis and systematic review was to explore the efficacy of tiotropium in treating patients with moderate-to-severe asthma on the basis of qualified randomized controlled trials (RCTs). Methods: The… read more here.

Keywords: severe asthma; efficacy tiotropium; moderate severe; tiotropium treating ... See more keywords

Cost-effectiveness of the fixed-dose combination tiotropium/olodaterol versus tiotropium monotherapy or a fixed-dose combination of long-acting β2-agonist/inhaled corticosteroid for COPD in Finland, Sweden and the Netherlands: a model-based study

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recommendations! Published in 2021 at "BMJ Open"

DOI: 10.1136/bmjopen-2021-049675

Abstract: Objectives Chronic obstructive pulmonary disease (COPD) guidelines advocate treatment with combinations of long-acting bronchodilators for patients with COPD who have persistent symptoms or continue to have exacerbations while using a single bronchodilator. This study assessed… read more here.

Keywords: tiotropium olodaterol; tiotropium; finland sweden; fixed dose ... See more keywords

Managing Severe Asthma: A Role for the Long-Acting Muscarinic Antagonist Tiotropium

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recommendations! Published in 2018 at "BioMed Research International"

DOI: 10.1155/2018/7473690

Abstract: Severe asthma is associated with substantial morbidity and mortality. Therapies must be maximized to gain control of a patient's severe asthma; however, avoiding overtreatment is also important. The mainstays of asthma maintenance treatment are inhaled… read more here.

Keywords: antagonist tiotropium; muscarinic antagonist; long acting; tiotropium ... See more keywords

Safety of tiotropium in patients with asthma

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recommendations! Published in 2019 at "Therapeutic Advances in Respiratory Disease"

DOI: 10.1177/1753466618824010

Abstract: Given the high proportion of patients with asthma who remain uncontrolled despite controller treatment, there remains a need for the development of more effective treatment options with a proven safety and tolerability profile. Recently, asthma… read more here.

Keywords: safety tiotropium; tiotropium; safety tolerability; safety ... See more keywords