The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation.
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DOI: 10.1016/j.celrep.2017.12.096
Abstract: Cancer cells exploit the epithelial-to-mesenchymal transition (EMT) program to become metastatic. Cytoskeletal regulators are required in mesenchymal cells where they promote EMT and EMT-induced migration. In a search for regulators of metastasis, we conducted shRNA… read more here.
Keywords: hectd1; degradation; acf7; ligase hectd1 ... See more keywords