PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cell"
DOI: 10.1016/j.molcel.2017.01.019
Abstract: Summary Protein post-translation modification plays an important role in regulating DNA repair; however, the role of arginine methylation in this process is poorly understood. Here we identify the arginine methyltransferase PRMT5 as a key regulator… read more here.
Keywords: methylation; homologous recombination; prmt5; tip60 ... See more keywords
Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04363-w
Abstract: Obesity is characterized by excessive fatty acid conversion to triacylglycerols (TAGs) in adipose tissues. However, how signaling networks sense fatty acids and connect to the stimulation of lipid synthesis remains elusive. Here, we show that… read more here.
Keywords: acetylation; fatty acid; fatty acids; translocation ... See more keywords
Structure of the human TIP60 complex
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51259-z
Abstract: Mammalian TIP60 is a multi-functional enzyme with histone acetylation and histone dimer exchange activities. It plays roles in diverse cellular processes including transcription, DNA repair, cell cycle control, and embryonic development. Here we report the… read more here.
Keywords: module; tip60; tip60 complex; human tip60 ... See more keywords
Tip60 HAT activators as therapeutic modulators for Alzheimer’s disease
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DOI: 10.1038/s41467-025-58496-w
Abstract: Reduced histone acetylation in the brain causes transcriptional dysregulation and cognitive impairment that are key initial steps in Alzheimer’s disease (AD) etiology. Unfortunately, current treatment strategies primarily focus on histone deacetylase inhibition (HDACi) that causes… read more here.
Keywords: alzheimer disease; tip60; acetylation; tip60 hat ... See more keywords
Abstract 3: TIP60 modulates colorectal cancer stemness through cd44 expression
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3
Abstract: To identify the functional role of TIP60 in regulating colorectal cancer (CRC) stemness. The HCT116 CRC cell lines were cultured in DMEM (high glucose) supplemented with 10% FBS. ShRNA-mediated depletion of TIP60 was generated using… read more here.
Keywords: colorectal cancer; cancer; tip60; stemness ... See more keywords
The CK1δ/ϵ-Tip60 Axis Enhances Wnt/β-Catenin Signaling via Regulating β-Catenin Acetylation in Colon Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.844477
Abstract: Casein kinase 1δ/ϵ (CK1δ/ϵ) are well-established positive modulators of the Wnt/β-catenin signaling pathway. However, the molecular mechanisms involved in the regulation of β-catenin transcriptional activity by CK1δ/ϵ remain unclear. In this study, we found that… read more here.
Keywords: tip60; colon cancer; catenin acetylation; catenin ... See more keywords
Chelidonium majus Induces Apoptosis of Human Ovarian Cancer Cells via ATF3-Mediated Regulation of Foxo3a by Tip60
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Microbiology and Biotechnology"
DOI: 10.4014/jmb.2109.09030
Abstract: Forkhead transcription factor 3a (Foxo3a) is believed to be a tumor suppressor as its inactivation leads to cell transformation and tumor development. However, further investigation is required regarding the involvement of the activating transcription factor… read more here.
Keywords: chelidonium majus; foxo3a; tip60; atf3 ... See more keywords