PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cell"
DOI: 10.1016/j.molcel.2017.01.019
Abstract: Summary Protein post-translation modification plays an important role in regulating DNA repair; however, the role of arginine methylation in this process is poorly understood. Here we identify the arginine methyltransferase PRMT5 as a key regulator… read more here.
Keywords: methylation; homologous recombination; prmt5; tip60 ... See more keywords
Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04363-w
Abstract: Obesity is characterized by excessive fatty acid conversion to triacylglycerols (TAGs) in adipose tissues. However, how signaling networks sense fatty acids and connect to the stimulation of lipid synthesis remains elusive. Here, we show that… read more here.
Keywords: acetylation; fatty acid; fatty acids; translocation ... See more keywords
The CK1δ/ϵ-Tip60 Axis Enhances Wnt/β-Catenin Signaling via Regulating β-Catenin Acetylation in Colon Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.844477
Abstract: Casein kinase 1δ/ϵ (CK1δ/ϵ) are well-established positive modulators of the Wnt/β-catenin signaling pathway. However, the molecular mechanisms involved in the regulation of β-catenin transcriptional activity by CK1δ/ϵ remain unclear. In this study, we found that… read more here.
Keywords: tip60; colon cancer; catenin acetylation; catenin ... See more keywords
Chelidonium majus Induces Apoptosis of Human Ovarian Cancer Cells via ATF3-Mediated Regulation of Foxo3a by Tip60
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Microbiology and Biotechnology"
DOI: 10.4014/jmb.2109.09030
Abstract: Forkhead transcription factor 3a (Foxo3a) is believed to be a tumor suppressor as its inactivation leads to cell transformation and tumor development. However, further investigation is required regarding the involvement of the activating transcription factor… read more here.
Keywords: chelidonium majus; foxo3a; tip60; atf3 ... See more keywords