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   Articles with "tipe1" as a keyword



Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202304940

Abstract: Inadequate β‐cell mass and insulin secretion are essential for the development of type 2 diabetes (T2D). TNF‐α‐induced protein 8‐like 1 (Tipe1) plays a crucial role in multiple diseases, however, a specific role in T2D pathogenesis… read more here.

Keywords: insulin secretion; tipe1; cell; beta cell ... See more keywords

Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy

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recommendations! Published in 2022 at "Redox Biology"

DOI: 10.1016/j.redox.2022.102260

Abstract: Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and are thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in tubular damage in diabetic nephropathy (DN). However,… read more here.

Keywords: damage; rtecs; tipe1; tubular epithelial ... See more keywords

TIPE1 suppresses the invasion and migration of breast cancer cells and inhibits epithelial-to-mesenchymal transition primarily via the ERK signaling pathway.

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recommendations! Published in 2019 at "Acta biochimica et biophysica Sinica"

DOI: 10.1093/abbs/gmz099

Abstract: Tumor necrosis factor α-induced protein 8-like-1 (TIPE1) functions as an activator or a repressor in a tumor cell type-specific manner. However, the role of TIPE1 in breast cancer, especially regarding metastasis, is unknown. In this… read more here.

Keywords: tipe1; breast cancer; epithelial mesenchymal; cancer cells ... See more keywords

Phosphoinositide-binding protein TIPE1 promotes alternative activation of macrophages and tumor progression via PIP3/Akt/TGF-β axis.

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recommendations! Published in 2022 at "Cancer research"

DOI: 10.1158/0008-5472.can-21-0003

Abstract: Macrophages perform key and distinct functions in maintaining tissue homeostasis by finely tuning their activation state. Within the tumor microenvironment, macrophages are reshaped to drive tumor progression. Here we report that tumor necrosis factor α-induced… read more here.

Keywords: tumor progression; activation; tumor; tipe1 ... See more keywords

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

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recommendations! Published in 2020 at "Oncology Letters"

DOI: 10.3892/ol.2020.12227

Abstract: Tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) functions as a tumor suppressor in several types of cancer, including lung and breast cancer. The present study aimed to determine the level of expression and the function… read more here.

Keywords: tipe1; expression; ovarian cancer; cancer ... See more keywords