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   Articles with "tir domain" as a keyword



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NAD+ Cleavage: TIR Domain-Containing Resistance Proteins in Action.

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recommendations! Published in 2019 at "Trends in plant science"

DOI: 10.1016/j.tplants.2019.10.005

Abstract: Plant resistance proteins play a key role in detecting pathogen infection and activating plant defense. Two recent papers by Horsefield et al. and Wan et al. revealed that the TIR domain in resistance (R) proteins functions as an NAD+-cleaving… read more here.

Keywords: tir domain; resistance proteins; resistance; nad cleavage ... See more keywords
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MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-22590-6

Abstract: MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation of crystalline higher-order… read more here.

Keywords: tir domain; higher order; assembly; myd88 tir ... See more keywords

Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-46499-y

Abstract: The occurrence of NAD^+ as a non-canonical RNA cap has been demonstrated in diverse organisms. TIR domain-containing proteins present in all kingdoms of life act in defense responses and can have NADase activity that hydrolyzes… read more here.

Keywords: nad rna; domain containing; tir domain; containing proteins ... See more keywords

The role of TIR domain-containing proteins in bacterial defense against phages

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-51738-3

Abstract: Toll/interleukin-1 receptor (TIR) domain-containing proteins play a critical role in immune responses in diverse organisms, but their function in bacterial systems remains to be fully elucidated. This study, focusing on Escherichia coli, addresses how TIR… read more here.

Keywords: domain containing; tir domain; containing proteins; defense ... See more keywords

Antiviral activity of bacterial TIR domains via immune signalling molecules.

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recommendations! Published in 2021 at "Nature"

DOI: 10.1038/s41586-021-04098-7

Abstract: The Toll/interleukin-1 receptor (TIR) domain is a canonical component of animal and plant immune systems1,2. In plants, intracellular pathogen sensing by immune receptors triggers their TIR domains to generate a molecule that is a variant… read more here.

Keywords: antiviral activity; tir domain; bacterial tir; tir domains ... See more keywords

TIR-domain-containing protein C as modulator of innate immune checkpoints

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-29677-w

Abstract: The TIR-domain-containing protein C (TcpC), a virulence factor of the uropathogenic Escherichia coli strain CFT073, binds to crucial components of the toll-like receptor-signaling cascade and the NLRP3 inflammasome thus manipulating these innate immune checkpoints and… read more here.

Keywords: containing protein; tcpc; domain containing; tir domain ... See more keywords

Effect of oral resveratrol-loaded nanoliposomes on hyperlipidemia via toll-like receptor 3 and TIR domain-containing adaptor inducing interferon-β protein expression in an animal model

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recommendations! Published in 2025 at "Journal of Liposome Research"

DOI: 10.1080/08982104.2025.2476529

Abstract: Abstract Hyperlipidemia, a critical risk factor for various health conditions, necessitates innovative therapeutic strategies. Investigating the effectiveness of liposomal formulations in managing hyperlipidemia is essential. Resveratrol (RES)-loaded nanoliposomes present a promising new approach for hyperlipidemia… read more here.

Keywords: res loaded; toll like; like receptor; tir domain ... See more keywords
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Structural analysis of the Toll-like receptor 15 TIR domain

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recommendations! Published in 2023 at "IUCrJ"

DOI: 10.1107/s2052252523002956

Abstract: The intracellular TIR domain of TLR15 is likely to assemble into a unique dimer with distinct structures for the BB and DD loops and αC2 helix. read more here.

Keywords: tir; toll like; analysis toll; like receptor ... See more keywords

Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly

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recommendations! Published in 2024 at "Acta Crystallographica Section D: Structural Biology"

DOI: 10.1107/s2059798324008210

Abstract: This study addresses the structural basis of TIR-domain-mediated signal transduction in Toll-like receptor 2 pathways. It is demonstrated that TLR2, but not TLR1 or TLR6, TIR domains induce the formation of MyD88 TIR-domain assemblies in… read more here.

Keywords: toll like; tir; tir domain; like receptor ... See more keywords

Shared TIR enzymatic functions regulate cell death and immunity across the tree of life

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recommendations! Published in 2022 at "Science"

DOI: 10.1126/science.abo0001

Abstract: In the 20th century, researchers studying animal and plant signaling pathways discovered a protein domain that is shared across diverse innate immune systems: the Toll/interleukin-1/resistance gene (TIR) domain. The TIR domain is found in several… read more here.

Keywords: tir; tir domains; tir domain; activity ... See more keywords

Structural Evolution of TIR-Domain Signalosomes

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recommendations! Published in 2021 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.784484

Abstract: TIR (Toll/interleukin-1 receptor/resistance protein) domains are cytoplasmic domains widely found in animals and plants, where they are essential components of the innate immune system. A key feature of TIR-domain function in signaling is weak and… read more here.

Keywords: tir domain; structural evolution; tir domains; evolution tir ... See more keywords