NAD+ Cleavage: TIR Domain-Containing Resistance Proteins in Action.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in plant science"
DOI: 10.1016/j.tplants.2019.10.005
Abstract: Plant resistance proteins play a key role in detecting pathogen infection and activating plant defense. Two recent papers by Horsefield et al. and Wan et al. revealed that the TIR domain in resistance (R) proteins functions as an NAD+-cleaving… read more here.
Keywords: tir domain; resistance proteins; resistance; nad cleavage ... See more keywords
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
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DOI: 10.1038/s41467-021-22590-6
Abstract: MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation of crystalline higher-order… read more here.
Keywords: tir domain; higher order; assembly; myd88 tir ... See more keywords
Antiviral activity of bacterial TIR domains via immune signalling molecules.
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DOI: 10.1038/s41586-021-04098-7
Abstract: The Toll/interleukin-1 receptor (TIR) domain is a canonical component of animal and plant immune systems1,2. In plants, intracellular pathogen sensing by immune receptors triggers their TIR domains to generate a molecule that is a variant… read more here.
Keywords: antiviral activity; tir domain; bacterial tir; tir domains ... See more keywords
Structural analysis of the Toll-like receptor 15 TIR domain
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DOI: 10.1107/s2052252523002956
Abstract: The intracellular TIR domain of TLR15 is likely to assemble into a unique dimer with distinct structures for the BB and DD loops and αC2 helix. read more here.
Keywords: tir; toll like; analysis toll; like receptor ... See more keywords
Shared TIR enzymatic functions regulate cell death and immunity across the tree of life
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DOI: 10.1126/science.abo0001
Abstract: In the 20th century, researchers studying animal and plant signaling pathways discovered a protein domain that is shared across diverse innate immune systems: the Toll/interleukin-1/resistance gene (TIR) domain. The TIR domain is found in several… read more here.
Keywords: tir; tir domains; tir domain; activity ... See more keywords
Structural Evolution of TIR-Domain Signalosomes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.784484
Abstract: TIR (Toll/interleukin-1 receptor/resistance protein) domains are cytoplasmic domains widely found in animals and plants, where they are essential components of the innate immune system. A key feature of TIR-domain function in signaling is weak and… read more here.
Keywords: tir domain; structural evolution; tir domains; evolution tir ... See more keywords