Antiviral activity of bacterial TIR domains via immune signalling molecules.
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DOI: 10.1038/s41586-021-04098-7
Abstract: The Toll/interleukin-1 receptor (TIR) domain is a canonical component of animal and plant immune systems1,2. In plants, intracellular pathogen sensing by immune receptors triggers their TIR domains to generate a molecule that is a variant… read more here.
Keywords: antiviral activity; tir domain; bacterial tir; tir domains ... See more keywords
Shared TIR enzymatic functions regulate cell death and immunity across the tree of life
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DOI: 10.1126/science.abo0001
Abstract: In the 20th century, researchers studying animal and plant signaling pathways discovered a protein domain that is shared across diverse innate immune systems: the Toll/interleukin-1/resistance gene (TIR) domain. The TIR domain is found in several… read more here.
Keywords: tir; tir domains; tir domain; activity ... See more keywords
Structural Evolution of TIR-Domain Signalosomes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.784484
Abstract: TIR (Toll/interleukin-1 receptor/resistance protein) domains are cytoplasmic domains widely found in animals and plants, where they are essential components of the innate immune system. A key feature of TIR-domain function in signaling is weak and… read more here.
Keywords: tir domain; structural evolution; tir domains; evolution tir ... See more keywords