Semi-mechanistic PK/PD modeling and simulation of irreversible BTK inhibition to support dose selection of tirabrutinib in subjects with RA.
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DOI: 10.1002/cpt.2439
Abstract: Tirabrutinib is an irreversible, small-molecule Bruton's tyrosine kinase (BTK) inhibitor, which was approved in Japan (VELEXBRU® ) to treat B-cell malignancies and is in clinical development for inflammatory diseases. As an application of model-informed drug… read more here.
Keywords: tirabrutinib; semi mechanistic; model; btk ... See more keywords
Long-term follow-up of patients with mantle cell lymphoma (MCL) treated with the selective Bruton’s tyrosine kinase inhibitor tirabrutinib (GS/ONO-4059)
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DOI: 10.1038/s41375-019-0658-7
Abstract: Recent therapeutic advances for mantle cell lymphoma (MCL) include inhibitors of Bruton’s tyrosine kinase (BTK), a critical component in the B-cell receptor signaling pathway [1, 2]. Remarkably, approximately two thirds of patients with relapsed/refractory (R/R)… read more here.
Keywords: mcl; response; tirabrutinib; study ... See more keywords
Evaluation of the potential for pharmacokinetic interaction between tirabrutinib and levonorgestrel/ethinyl estradiol in healthy female volunteers
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DOI: 10.1111/cts.13265
Abstract: Tirabrutinib (TIRA), a potent and nonreversible oral Bruton tyrosine kinase inhibitor, is evaluated for treatment of certain hematological malignancies and inflammatory diseases. A drug–drug interaction study to evaluate the effect of TIRA on the pharmacokinetics… read more here.
Keywords: interaction; healthy female; tira; levo ... See more keywords
Bing-Neel Syndrome Successfully Treated with Tirabrutinib
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DOI: 10.2169/internalmedicine.9545-22
Abstract: Bing-Neel syndrome (BNS) is a rare central nervous system manifestation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM). We herein report a 62-year-old man with LPL/WM after multiple chemotherapies. He had weakness of lower extremities and elevated serum… read more here.
Keywords: treated tirabrutinib; neel syndrome; syndrome successfully; successfully treated ... See more keywords