Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.01.039
Abstract: The molecular basis of the incomplete penetrance of monogenic disorders is unclear. We describe here eight related individuals with autosomal recessive TIRAP deficiency. Life-threatening staphylococcal disease occurred during childhood in the proband, but not in… read more here.
Keywords: immunity; tlr2; tirap; anti lta ... See more keywords
MAL adaptor (TIRAP) S180L polymorphism and severity of disease among tuberculosis patients
Sign Up to like & getrecommendations! Published in 2020 at "Infection, Genetics and Evolution"
DOI: 10.1016/j.meegid.2019.104093
Abstract: Abstract Objective Though several genetic variants have been recognized to be associated with susceptibility to Tuberculosis (TB) infection and disease, a recent observation on the association of TIRAP C975T (S180L) variants with TB disease severity… read more here.
Keywords: tuberculosis; tirap; severity; association ... See more keywords
Tirap controls Mycobacterium tuberculosis phagosomal acidification
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011192
Abstract: Progression of tuberculosis is tightly linked to a disordered immune balance, resulting in inability of the host to restrict intracellular bacterial replication and its subsequent dissemination. The immune response is mainly characterized by an orchestrated… read more here.
Keywords: mycobacterium tuberculosis; tuberculosis; tirap; mtb infection ... See more keywords