Effect of Intracoronary Tirofiban Through Guiding Catheter Compared With Intracoronary Tirofiban Through Aspiration Catheter on the Microvascular Obstruction in Patients With STEMI Undergoing PCI: A Cardiac MR Study
Sign Up to like & getrecommendations! Published in 2025 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.31665
Abstract: Myocardial infarction (MI) is a major global cause of morbidity and mortality. Reperfusion therapy in acute MI reduces mortality, but microvascular obstruction (MVO) may persist. Tirofiban improves myocardial perfusion by inhibiting platelet aggregation. read more here.
Keywords: catheter; intracoronary tirofiban; tirofiban; microvascular obstruction ... See more keywords
Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model
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DOI: 10.1038/s41467-024-52869-3
Abstract: Venous thrombosis (VT) is a common vascular disease associated with reduced survival and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at sites of endothelial cell activation. A role… read more here.
Keywords: role; venous thrombogenesis; platelet; tirofiban ... See more keywords
Safety and efficacy of prophylactic tirofiban infusion for acute intracranial intraprocedural stent thrombosis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00872-9
Abstract: Periprocedural antithrombotic management with glycoprotein IIb/IIIa inhibitors (GPI) for intracranial artery stenting is still controversial. We sought to assess the safety and efficacy of prophylactic tirofiban infusion for acute intracranial intraprocedural stent thrombosis in routine… read more here.
Keywords: tirofiban group; stent thrombosis; safety; prophylactic tirofiban ... See more keywords
Clinical efficacy and safety of tirofiban combined with conventional dual antiplatelet therapy in ACS patients undergoing PCI
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DOI: 10.1038/s41598-021-96606-y
Abstract: Challenges remain for clinicians over balancing the efficacy of active antithrombotic therapy and simultaneous bleeding reduction in patients. The clinical data of 347 patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) were… read more here.
Keywords: group group; group; acs patients; efficacy ... See more keywords
Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2078489
Abstract: Abstract We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry. To do so,… read more here.
Keywords: platelet activation; aggregation; tirofiban; degranulation ... See more keywords
Comparison of Ischemic and Bleeding Events Between Short-Duration Versus Long-Duration Tirofiban Regimens in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001289
Abstract: Abstract: Tirofiban has been used historically as a bridge to platelet inhibition with clopidogrel in ST-segment myocardial infarction (STEMI) during percutaneous coronary intervention (PCI) to prevent stent thrombosis. However, ticagrelor and prasugrel reach similar levels… read more here.
Keywords: tirofiban; long duration; myocardial infarction; short duration ... See more keywords
Tirofiban in Suspected Left Ventricular Assist Device Pump Thrombosis.
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DOI: 10.1097/mat.0000000000001083
Abstract: Antithrombotic optimization with a glycoprotein IIb/IIIa inhibitor has been used for the treatment of suspected pump thrombosis, but available literature with tirofiban is lacking. This study aims to describe the use of tirofiban for suspected… read more here.
Keywords: tirofiban suspected; pump thrombosis; left ventricular; suspected pump ... See more keywords
Efficacy and safety of tirofiban in patients with acute branch atheromatous disease-related stroke (BRANT): a protocol for a randomised controlled trial
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DOI: 10.1136/bmjopen-2023-082141
Abstract: Introduction Branch atheromatous disease (BAD)-related stroke is increasingly becoming a clinical entity and prone to early neurological deterioration (END) and poor prognosis. There are no effective regimens to reduce the disability caused by BAD-related stroke… read more here.
Keywords: stroke; branch atheromatous; trial; tirofiban ... See more keywords
Validation of an in vitro testing platform for intra-arterial thrombolytics on human thrombectomy retrieved clots
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DOI: 10.1136/jnis-2025-023809
Abstract: Background Endovascular thrombectomy (EVT) is the standard treatment for acute ischemic stroke (AIS) due to large vessel occlusion. However, many patients fail to achieve good outcomes, especially without first pass reperfusion. Intra-arterial thrombolytics such as… read more here.
Keywords: arterial thrombolytics; clot; tirofiban; intra arterial ... See more keywords
Association of Intravenous Tirofiban with Functional Outcomes in Acute Ischemic Stroke Patients with Acute Basilar Artery Occlusion Receiving Endovascular Thrombectomy.
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DOI: 10.1159/000527483
Abstract: INTRODUCTION The aim of this study was to test the hypothesis that intravenous tirofiban improves functional outcomes without promoting the risk of intracranial hemorrhage (ICH) in stroke secondary to basilar artery occlusion (BAO) receiving endovascular… read more here.
Keywords: intravenous tirofiban; tirofiban; endovascular thrombectomy; tirofiban group ... See more keywords
Endovascular Thrombectomy: Tirofiban Increases Bleeding Risk in Acute Stroke Patients
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DOI: 10.1161/strokeaha.118.022919
Abstract: Background and Purpose— This study aimed to explore safety of tirofiban in endovascular treatment of acute ischemic stroke. Methods— Two hundred eighteen ischemic stroke patients receiving endovascular thrombectomy were prospectively recruited, with 94 treated with… read more here.
Keywords: ischemic stroke; thrombectomy tirofiban; stroke patients; endovascular thrombectomy ... See more keywords