TIRR: a potential front runner in HDR race−hypotheses and perspectives
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05285-x
Abstract: The majority of CRISPR-Cas9 methods for mutations correction are oriented on gene editing through homologous recombination that is normally restrained by non-homologous end joining (NHEJ). A recently identified protein TIRR can bind a 53BP1 protein,… read more here.
Keywords: hdr race; tirr; tirr potential; potential front ... See more keywords
TIRR and 53BP1- partners in arms
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1337966
Abstract: 53BP1 is a central player in the repair of DNA-double strand breaks (DSBs) as it orchestrates the choice between the DSB repair pathways, non-homologous end-joining (NHEJ) and homologous recombination (HR). 53BP1 promotes repair by NHEJ… read more here.
Keywords: recruitment; tirr 53bp1; brca1; tirr ... See more keywords