Relevance of charged and polar amino acids for functionality of membrane toxin TisB
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DOI: 10.1038/s41598-024-73879-7
Abstract: Bacterial dormancy is marked by reduced cellular activity and the suspension of growth. It represents a valuable strategy to survive stressful conditions, as exemplified by the long-term tolerance towards antibiotics that is attributable to a… read more here.
Keywords: functionality; amino acids; tisb; amino ... See more keywords
Escherichia coli type I toxin TisB exclusively controls proton depolarization following antibiotic induced DNA damage
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DOI: 10.1038/s41598-025-96136-x
Abstract: Bacterial toxin-antitoxin (TA) systems are genetic loci where the antitoxin gene product helps to control the expression or activity of the toxin gene product. Type I TA systems typically produce hydrophobic peptides that often localize… read more here.
Keywords: escherichia coli; depolarization; exclusively controls; tisb ... See more keywords
TisB Protein Protects Escherichia coli Cells Suffering Massive DNA Damage from Environmental Toxic Compounds
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DOI: 10.1128/mbio.00385-22
Abstract: The contribution of toxin-antitoxin systems to the persistence of bacteria to antibiotics has been intensively studied. This is also the case with the E. coli TisB/IstR toxin-antitoxin system, but the contribution of TisB to the… read more here.
Keywords: toxin antitoxin; tisb; antitoxin system; escherichia coli ... See more keywords