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   Articles with "tissue" as a keyword



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Association of Somatic ATP2A2 Damaging Variants With Grover Disease.

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recommendations! Published in 2023 at "JAMA dermatology"

DOI: 10.1001/jamadermatol.2023.1139

Abstract: Importance Grover disease (GD), a truncal eruption that typically occurs in older individuals, is exacerbated by sweating, irradiation, cancers, medications, kidney failure, and organ transplantation. The pathobiology of GD remains unknown. Objective To determine if… read more here.

Keywords: somatic atp2a2; disease; atp2a2 snvs; grover disease ... See more keywords
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Association of Cerebral Blood Flow With Longitudinal Changes in Cerebral Microstructural Integrity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

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recommendations! Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2022.31189

Abstract: Key Points Question Is cerebral blood supply associated with cerebral tissue integrity? Findings In this cohort study of 732 healthy adults, at 5-year follow-up, significant associations between lower regional cerebral blood flow and decreased integrity… read more here.

Keywords: cerebral blood; blood; integrity; blood flow ... See more keywords
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Adipocyte‐specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14335

Abstract: Adipose tissue regulates whole‐body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin‐dependent kinases (CDKs) have been reported to… read more here.

Keywords: adipocyte specific; adipose tissue; dysfunction; specific cdk7 ... See more keywords
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A combined tissue‐engineered/in silico signature tool patient stratification in lung cancer

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recommendations! Published in 2018 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12323

Abstract: Patient‐tailored therapy based on tumor drivers is promising for lung cancer treatment. For this, we combined in vitro tissue models with in silico analyses. Using individual cell lines with specific mutations, we demonstrate a generic… read more here.

Keywords: stratification; treatment; tissue; drug ... See more keywords
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High‐throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12570

Abstract: Formalin‐fixed, paraffin‐embedded (FFPE), biobanked tissue samples offer an invaluable resource for clinical and biomarker research. Here, we developed a pressure cycling technology (PCT)‐SWATH mass spectrometry workflow to analyze FFPE tissue proteomes and applied it to… read more here.

Keywords: stratification; ffpe samples; tissue samples; ffpe ... See more keywords
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Concordance between TP53 alterations in blood and tissue: impact of time interval, biopsy site, cancer type and circulating tumor DNA burden

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recommendations! Published in 2020 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12672

Abstract: We examined the impact of spatial, temporal, histologic, and quantitative factors on concordance between TP53 alterations in tissue DNA vs in circulating tumor DNA (ctDNA). Four hundred and thirty‐three patients underwent next‐generation sequencing (NGS) in… read more here.

Keywords: tp53 alterations; dna; concordance; tissue ... See more keywords
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Combined RNA/tissue profiling identifies novel Cancer/Testis genes.

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recommendations! Published in 2021 at "Molecular oncology"

DOI: 10.1002/1878-0261.12900

Abstract: Cancer/Testis (CT) genes are induced in germ cells, repressed in somatic cells and de-repressed in somatic tumors, where these genes can contribute to cancer progression. CT gene identification requires data obtained using standardized protocols and… read more here.

Keywords: testis; tissue; testis genes; cancer testis ... See more keywords
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The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13275

Abstract: Aging represents the major risk factor for the development of cancer and many other diseases. Recent findings show that normal tissues become riddled with expanded clones that are frequently driven by cancer‐associated mutations in an… read more here.

Keywords: somatic mutational; mutational landscapes; disease; cancer ... See more keywords
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Postoperative circulating tumor DNA can refine risk stratification in resectable lung cancer: results from a multicenter study

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recommendations! Published in 2023 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13387

Abstract: Circulating tumor DNA (ctDNA) has potential as a promising biomarker for molecular residual disease (MRD) detection in lung cancer. As the next‐generation sequencing standardized panel for ctDNA detection emerges, its clinical utility needs to be… read more here.

Keywords: resectable lung; lung cancer; ctdna; lung ... See more keywords
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Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12276

Abstract: Glutamate carboxypeptidase II (GCPII), also known as prostate‐specific membrane antigen (PSMA) or folate hydrolase, is a metallopeptidase expressed predominantly in the human brain and prostate. GCPII expression is considerably increased in prostate carcinoma, and the… read more here.

Keywords: prostate; gcpii; human gcpii; tissue ... See more keywords
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Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy

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recommendations! Published in 2021 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13083

Abstract: Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage. Herein, we investigated the activity of XOR in… read more here.

Keywords: activity; tissue; model aristolochic; xor ... See more keywords