Optimal Bayesian hierarchical model to accelerate the development of tissue-agnostic drugs and basket trials.
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106460
Abstract: Tissue-agnostic trials and basket trials enroll patients based on their genetic biomarkers, not tumor type, in an attempt to determine if a new drug can successfully treat disease conditions based on biomarkers. The Bayesian hierarchical… read more here.
Keywords: tissue; tissue agnostic; bayesian hierarchical; basket trials ... See more keywords
In a major shift, cancer drugs go 'tissue-agnostic'.
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.356.6343.1111
Abstract: Since the beginnings of cancer chemotherapy in the 1940s, oncologists have treated patients with drugs based on the organ or tissue where their tumors originated. Colon cancer requires different drug regimens than lung, breast, or… read more here.
Keywords: cancer drugs; shift cancer; drug; major shift ... See more keywords
Tissue-Agnostic Activity of BRAF plus MEK Inhibitor in BRAF V600–Mutant Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-21-0950
Abstract: Abstract BRAF plus MEK inhibitor combinations are currently FDA-approved for melanoma, non–small cell lung cancer, and anaplastic thyroid cancer. The lack of clinical benefit with BRAF inhibition in BRAF V600–mutated colorectal cancer has prevented its… read more here.
Keywords: braf plus; braf v600; braf; inhibitor ... See more keywords
Review and Prospect of Tissue-agnostic targeted Strategies in Anticancer therapies.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026620666200616143247
Abstract: Due to the increasing prevalence of cancer year by year, and the complexity and refractory nature of the disease itself, it is required to constantly innovate the development of new cancer treatment schemes. At the… read more here.
Keywords: anticancer therapies; targeted therapy; tissue agnostic; review prospect ... See more keywords