The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00666-9
Abstract: The excess deposition of underlying extracellular matrix (ECM) in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder such as obesity and type 2 diabetes. Anti-fibrosis therapy has… read more here.
Keywords: adipokine orosomucoid; via ampk; tissue; adipose tissue ... See more keywords
Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73194-x
Abstract: The role of fibroblasts in tissue fibrosis has been extensively studied. Activated fibroblasts, namely myofibroblasts, produce pathological extracellular matrix. CD248, a type I transmembrane glycoprotein, is expressed in fibroblasts after birth. In human chronic kidney… read more here.
Keywords: cd248 mice; fibrosis; cd248; tissue fibrosis ... See more keywords
Polydopamine-assisted tranilast immobilization on a PLA chamber to enhance fat flaps regeneration by reducing tissue fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra05237g
Abstract: Tissue engineering chambers (TECs) have been shown to be useful in regenerating adipose tissue. However, tissue fibrosis caused by the chambers compromises the final volume of the newly formed adipose tissue. Surface modifications can compensate… read more here.
Keywords: regeneration; chamber; pla chamber; tissue ... See more keywords
Autophagy-inducing natural compounds: a treasure resource for developing therapeutics against tissue fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2017.1279151
Abstract: Abstract Tissue fibrosis is a common pathologic change of many chronic diseases, which is characterized by extracellular matrix accumulation in tissues and dysfunction of the injured organs. Despite there recently gain mechanistic insight into the… read more here.
Keywords: natural compounds; therapeutics tissue; fibrosis; autophagy inducing ... See more keywords
Saponins from Panax japonicus alleviate adipose tissue fibrosis and metabolic dysfunction in high-fat-diet-induced obese mice
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2122566
Abstract: ABSTRACT Introduction Adipose tissue fibrosis is a typical feature of adipose tissue dysfunction in obese individuals, which is closely related to metabolic diseases. Objective To explore the effect and mechanism of Saponins from Panax japonicus… read more here.
Keywords: obese mice; adipose tissue; saponins panax; fibrosis ... See more keywords
Far-Infrared Radiation Thermotherapy Improves Tissue Fibrosis in Chronic Extremity Lymphedema.
Sign Up to like & getrecommendations! Published in 2018 at "Lymphatic research and biology"
DOI: 10.1089/lrb.2016.0057
Abstract: BACKGROUND Fibrosis can enhance the exacerbation of lymphedema, which becomes obvious in late stage II-III lymphedema. However, whether far-infrared radiation thermotherapy (FIRT) can cure lymphedema fibrosis is still lack of research. This research was to… read more here.
Keywords: fibrosis; extremity; treatment; tissue fibrosis ... See more keywords
Cholestasis-Associated Pulmonary Inflammation, Oxidative Stress, and Tissue Fibrosis: The Protective Role of the Biogenic Amine Agmatine.
Sign Up to like & getrecommendations! Published in 2023 at "Pharmacology"
DOI: 10.1159/000530307
Abstract: INTRODUCTION Cholestasis is the stoppage of bile flow, leading to the accumulation of potentially cytotoxic bile components in the liver. These cytotoxic molecules affect many organs. Cholestasis-induced lung injury is a severe complication that could… read more here.
Keywords: cholestasis; oxidative stress; tissue fibrosis;
Evitar (l-Alanyl-l-Glutamine) Regulates Key Signaling Molecules in the Pathogenesis of Postoperative Tissue Fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive Sciences"
DOI: 10.1177/1933719118789511
Abstract: Aims: Hypoxia and the resulting oxidative stress play a major role in postoperative tissue fibrosis. The objective of this study was to determine the effect of l-alanyl-l-glutamine (Ala-Gln) on key markers of postoperative tissue fibrosis:… read more here.
Keywords: tissue; tissue fibrosis; hypoxia; postoperative tissue ... See more keywords
Abrogation of transforming growth factor-β-induced tissue fibrosis in TBRIcaCol1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib)
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0196559
Abstract: Transforming growth factor-β (TGF-β) plays a crucial role in the pathogenesis of Systemic Sclerosis (SSc) and other fibrotic disorders. TGF-β-mediated c-Abl and Src kinase activation induces strong profibrotic cascade signaling. The purpose of this study… read more here.
Keywords: bosutinib; kinase inhibitor; fibrosis; tissue fibrosis ... See more keywords
Ongoing Clinical Trials in Aging-Related Tissue Fibrosis and New Findings Related to AhR Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Aging and Disease"
DOI: 10.14336/ad.2021.1105
Abstract: Fibrosis is a pathological manifestation of wound healing that replaces dead/damaged tissue with collagen-rich scar tissue to maintain homeostasis, and complications from fibrosis contribute to nearly half of all deaths in the industrialized world. Ageing… read more here.
Keywords: ongoing clinical; clinical trials; trials aging; tissue ... See more keywords
TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "Aging and disease"
DOI: 10.14336/ad.2023.0222
Abstract: Fibrosis is the abnormal accumulation of extracellular matrix proteins such as collagen and fibronectin. Aging, injury, infections, and inflammation can cause different types of tissue fibrosis. Numerous clinical investigations have shown a correlation between the… read more here.
Keywords: master regulator; tissue fibrosis; tissue; tgf master ... See more keywords