Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation
Sign Up to like & getrecommendations! Published in 2019 at "BioEssays"
DOI: 10.1002/bies.201800166
Abstract: Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the cartilage surface as well as controlling adhesionâdependent synovial growth and regulating bulk… read more here.
Keywords: proteoglycan mere; inflammation; tissue homeostasis; mere lubricant ... See more keywords
Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.03.014
Abstract: Regulatory TÂ cells (Treg cells) are important for preventing autoimmunity and maintaining tissue homeostasis, but whether Treg cells can adopt tissue- or immune-context-specific suppressive mechanisms is unclear. Here, we found that the enzyme hydroxyprostaglandin dehydrogenase (HPGD),… read more here.
Keywords: treg cells; hpgd; tissue homeostasis; adipose tissue ... See more keywords
Functional buffering via cell-specific gene expression promotes tissue homeostasis and cancer robustness
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-06813-4
Abstract: Functional buffering that ensures biological robustness is critical for maintaining tissue homeostasis, organismal survival, and evolution of novelty. However, the mechanism underlying functional buffering, particularly in multicellular organisms, remains largely elusive. Here, we proposed that… read more here.
Keywords: expression; robustness; functional buffering; buffering ... See more keywords
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1569914
Abstract: ABSTRACT The intronic hexanucleotide expansion in the C9orf72 gene is one of the leading causes of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), two devastating neurodegenerative diseases. C9orf72 forms a heterodimer with SMCR8… read more here.
Keywords: mtorc1; smcr8; c9orf72; tissue homeostasis ... See more keywords
Interleukin (IL)-33 and the IL-1 Family of Cytokines-Regulators of Inflammation and Tissue Homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a028506
Abstract: Cytokines play an integral role in shaping innate and adaptive immune responses. Members of the interleukin (IL)-1 family regulate a plethora of immune-cell-mediated processes, which include pathogen defense and tissue homeostasis. Notably, the IL-1 family… read more here.
Keywords: interleukin family; tissue homeostasis; family; tissue ... See more keywords
Abstract A19: Conditional inactivation of SHOC2 in adult mice to study its role in tissue homeostasis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras18-a19
Abstract: The RAS-RAF-MEK-ERK signaling pathway plays an important role throughout mammalian development, from embryogenesis to tissue-specific cellular homeostasis, and its aberrant activation is a major driver of human cancer. Mouse models have highly improved our current… read more here.
Keywords: role; mice; tissue homeostasis; tissue ... See more keywords
A lifetime of stress: ATF6 in development and homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-018-0453-1
Abstract: BackgroundActivating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic… read more here.
Keywords: homeostasis; atf6; tissue homeostasis; stress ... See more keywords
The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02230-y
Abstract: Background Microglia cells represent the resident innate immune cells of the retina and are important for retinal development and tissue homeostasis. However, dysfunctional microglia can have a negative impact on the structural and functional integrity… read more here.
Keywords: homeostasis; interferon regulatory; regulatory factor; tissue homeostasis ... See more keywords
Control of tissue homeostasis, tumorigenesis, and degeneration by coupled bidirectional bistable switches.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS computational biology"
DOI: 10.1371/journal.pcbi.1009606
Abstract: The Hippo-YAP/TAZ signaling pathway plays a critical role in tissue homeostasis, tumorigenesis, and degeneration disorders. The regulation of YAP/TAZ levels is controlled by a complex regulatory network, where several feedback loops have been identified. However,… read more here.
Keywords: tumorigenesis degeneration; tissue homeostasis; tissue; coupled bidirectional ... See more keywords
Neural Tissue Homeostasis and Repair Is Regulated via CS and DS Proteoglycan Motifs
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.696640
Abstract: Chondroitin sulfate (CS) is the most abundant and widely distributed glycosaminoglycan (GAG) in the human body. As a component of proteoglycans (PGs) it has numerous roles in matrix stabilization and cellular regulation. This chapter highlights… read more here.
Keywords: cns pns; tissue homeostasis; neural tissue; tissue ... See more keywords
Function of Innate Lymphoid Cells in Periodontal Tissue Homeostasis: A Narrative Review
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076099
Abstract: Periodontitis is an irreversible inflammatory response that occurs in periodontal tissues. Given the size and diversity of natural flora in the oral mucosa, host immunity must strike a balance between pathogen identification and a complicated… read more here.
Keywords: tissue homeostasis; innate lymphoid; periodontal tissue; tissue ... See more keywords