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   Articles with "tissue homeostasis" as a keyword



Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation

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recommendations! Published in 2019 at "BioEssays"

DOI: 10.1002/bies.201800166

Abstract: Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the cartilage surface as well as controlling adhesion‐dependent synovial growth and regulating bulk… read more here.

Keywords: proteoglycan mere; inflammation; tissue homeostasis; mere lubricant ... See more keywords

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

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recommendations! Published in 2019 at "Immunity"

DOI: 10.1016/j.immuni.2019.03.014

Abstract: Regulatory T cells (Treg cells) are important for preventing autoimmunity and maintaining tissue homeostasis, but whether Treg cells can adopt tissue- or immune-context-specific suppressive mechanisms is unclear. Here, we found that the enzyme hydroxyprostaglandin dehydrogenase (HPGD),… read more here.

Keywords: treg cells; hpgd; tissue homeostasis; adipose tissue ... See more keywords

Functional buffering via cell-specific gene expression promotes tissue homeostasis and cancer robustness

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recommendations! Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-022-06813-4

Abstract: Functional buffering that ensures biological robustness is critical for maintaining tissue homeostasis, organismal survival, and evolution of novelty. However, the mechanism underlying functional buffering, particularly in multicellular organisms, remains largely elusive. Here, we proposed that… read more here.

Keywords: expression; robustness; functional buffering; buffering ... See more keywords

SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis

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recommendations! Published in 2019 at "Autophagy"

DOI: 10.1080/15548627.2019.1569914

Abstract: ABSTRACT The intronic hexanucleotide expansion in the C9orf72 gene is one of the leading causes of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), two devastating neurodegenerative diseases. C9orf72 forms a heterodimer with SMCR8… read more here.

Keywords: mtorc1; smcr8; c9orf72; tissue homeostasis ... See more keywords

Interleukin (IL)-33 and the IL-1 Family of Cytokines-Regulators of Inflammation and Tissue Homeostasis.

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recommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"

DOI: 10.1101/cshperspect.a028506

Abstract: Cytokines play an integral role in shaping innate and adaptive immune responses. Members of the interleukin (IL)-1 family regulate a plethora of immune-cell-mediated processes, which include pathogen defense and tissue homeostasis. Notably, the IL-1 family… read more here.

Keywords: interleukin family; tissue homeostasis; family; tissue ... See more keywords

Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis

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recommendations! Published in 2024 at "Science"

DOI: 10.1126/science.adk9880

Abstract: Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive… read more here.

Keywords: monitoring deep; homeostasis; shape adaptive; deep tissue ... See more keywords

Abstract LT04: Dissecting Mediator Kinase Activity in Normal Tissue Homeostasis and Cancer

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.fcs2023-lt04

Abstract: Cyclin-dependent kinase 8 (CDK8) and its paralog CDK19, collectively known as Mediator kinase, are part of the multimeric Mediator complex that fine-tune gene expression programs on multiple levels, most notably by controlling transcription factor (TF)… read more here.

Keywords: cancer; mediator kinase; mediator; kinase ... See more keywords

Abstract A19: Conditional inactivation of SHOC2 in adult mice to study its role in tissue homeostasis

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recommendations! Published in 2020 at "Molecular Cancer Research"

DOI: 10.1158/1557-3125.ras18-a19

Abstract: The RAS-RAF-MEK-ERK signaling pathway plays an important role throughout mammalian development, from embryogenesis to tissue-specific cellular homeostasis, and its aberrant activation is a major driver of human cancer. Mouse models have highly improved our current… read more here.

Keywords: role; mice; tissue homeostasis; tissue ... See more keywords

A lifetime of stress: ATF6 in development and homeostasis

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recommendations! Published in 2018 at "Journal of Biomedical Science"

DOI: 10.1186/s12929-018-0453-1

Abstract: BackgroundActivating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic… read more here.

Keywords: homeostasis; atf6; tissue homeostasis; stress ... See more keywords

The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation

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recommendations! Published in 2021 at "Journal of Neuroinflammation"

DOI: 10.1186/s12974-021-02230-y

Abstract: Background Microglia cells represent the resident innate immune cells of the retina and are important for retinal development and tissue homeostasis. However, dysfunctional microglia can have a negative impact on the structural and functional integrity… read more here.

Keywords: homeostasis; interferon regulatory; regulatory factor; tissue homeostasis ... See more keywords

Adenosine diphosphate released from stressed cells triggers mitochondrial transfer to achieve tissue homeostasis

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recommendations! Published in 2024 at "PLOS Biology"

DOI: 10.1371/journal.pbio.3002753

Abstract: Cell-to-cell mitochondrial transfer has recently been shown to play a role in maintaining physiological functions of cell. We previously illustrated that mitochondrial transfer within osteocyte dendritic network regulates bone tissue homeostasis. However, the mechanism of… read more here.

Keywords: mitochondrial transfer; transfer; tissue homeostasis; adenosine diphosphate ... See more keywords