Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus.
Sign Up to like & getrecommendations! Published in 2018 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c170040
Abstract: The objective of this comprehensive review is to summarize and discuss the available evidence of how adipose tissue inflammation affects insulin sensitivity and glucose tolerance. Low-grade, chronic adipose tissue inflammation is characterized by infiltration of… read more here.
Keywords: insulin resistance; inflammation; adipose tissue; tissue inflammation ... See more keywords
Effects of colchicine on lipolysis and adipose tissue inflammation in adults with obesity and metabolic syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23341
Abstract: The aim of this study was to examine whether colchicine’s anti‐inflammatory effects would improve measures of lipolysis and distribution of leukocyte populations in subcutaneous adipose tissue (SAT). read more here.
Keywords: colchicine lipolysis; tissue inflammation; adipose tissue; lipolysis adipose ... See more keywords
Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4223-5
Abstract: Aims/hypothesisRecently, hedgehog (Hh) was identified as a crucial player in adipose tissue development and energy expenditure. Therefore, we tested whether Hh ligands are regulated in obesity. Further, we aimed at identifying potential target cells of… read more here.
Keywords: inflammation glucose; tissue; glucose metabolism; adipose tissue ... See more keywords
Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation.
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DOI: 10.1016/j.celrep.2020.107892
Abstract: Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous… read more here.
Keywords: tim cells; cells regulates; inflammation; receptor ... See more keywords
mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.06.052
Abstract: Background Mycobacterium tuberculosis has co-evolved with the human host, adapting to exploit the immune system for persistence and transmission. While immunity to tuberculosis (TB) has been intensively studied in the lung and lymphoid system, little… read more here.
Keywords: tuberculosis; mtorc2 akt; adipose tissue; tissue inflammation ... See more keywords
mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function.
Sign Up to like & getrecommendations! Published in 2017 at "Immunobiology"
DOI: 10.1016/j.imbio.2016.09.014
Abstract: Genetic- and diet-induced obesity and insulin resistance are associated with an increase in mechanistic target of rapamycin complex (mTORC) 1 activity in adipose tissue. We investigated herein the effects of pharmacological mTORC1 inhibition in the… read more here.
Keywords: mtorc1 inhibition; tissue; adipose tissue; rapamycin ... See more keywords
Reply: New Aspects of Vasospastic Angina: Coronary Adventitial and Perivascular Adipose Tissue Inflammation.
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DOI: 10.1016/j.jacc.2018.03.510
Abstract: We greatly appreciate Dr. Ciliberti and colleagues and Drs. Antonopoulos and Antoniades for their interests and comments on our recent study “Coronary adventitial and perivascular adipose tissue inflammation in patients with vasospastic angina” [(1)][1]. First,… read more here.
Keywords: coronary adventitial; perivascular adipose; adipose tissue; adventitial perivascular ... See more keywords
Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.06.015
Abstract: Objective The worldwide prevalence of obesity has increased to 10% in men and 15% in women and is associated with severe comorbidities such as diabetes, cancer, and cardiovascular disease. Animal models of obesity are central… read more here.
Keywords: tissue; extensive adipose; adipose tissue; obesity ... See more keywords
Unique B7-H1 expression on masticatory mucosae in the oral cavity and trans-coinhibition by B7-H1-expressing keratinocytes regulating CD4+ T cell-mediated mucosal tissue inflammation
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DOI: 10.1038/mi.2016.89
Abstract: The PD-1/B7-H1 pathway regulates immune responses and maintains homeostasis. Here, we identified a unique expression of B7 homolog 1 (B7-H1) on masticatory mucosae in the oral cavity. B7-H1 was physiologically expressed on the dorsal surface… read more here.
Keywords: masticatory mucosae; expression; cell; cd4 ... See more keywords
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation.
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DOI: 10.1038/s41590-021-01065-2
Abstract: Misdirected immunity gives rise to the autoimmune tissue inflammation of rheumatoid arthritis, in which excess production of the cytokine tumor necrosis factor (TNF) is a central pathogenic event. Mechanisms underlying the breakdown of self-tolerance are… read more here.
Keywords: mitochondrial aspartate; aspartate; autoimmune; tissue inflammation ... See more keywords
Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets.
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DOI: 10.1042/cs20200356
Abstract: Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies… read more here.
Keywords: flavonoids adipose; inflammation atherosclerosis; adipose tissue; tissue inflammation ... See more keywords