Transcriptional repression shapes the identity and function of tissue macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13269
Abstract: The changing extra- and intracellular microenvironment calls for rapid cell fate decisions that are precisely and primarily regulated at the transcriptional level. The cellular components of the immune system are excellent examples of how cells… read more here.
Keywords: tissue macrophages; tissue; function; identity ... See more keywords
Isolation and Analysis of Human Monocytes and Adipose Tissue Macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9130-3_3
Abstract: Monocytes and macrophages are cells of the innate immune system, existing in circulation and permeating every tissue of the human body. These cells represent the first responders to stress, and their inflammatory activation forms part… read more here.
Keywords: monocytes macrophages; tissue macrophages; isolation analysis; tissue ... See more keywords
Tissue macrophages as mediators of a healthy relationship with gut commensal microbiota.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.01.017
Abstract: Mammals and microorganisms have evolved a complex and tightly controlled mutual relationship. This interaction grants protection and energy source for the microorganisms, and on the other hand, provides several immunologic, metabolic and physiological advantages for… read more here.
Keywords: mediators healthy; tissue macrophages; macrophages mediators; healthy relationship ... See more keywords
HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.046
Abstract: Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation in the development of obesity-induced adipose-tissue inflammation,… read more here.
Keywords: tissue macrophages; tissue; lipid droplet; adipose tissue ... See more keywords
Endocardially Derived Macrophages Are Essential for Valvular Remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.01.021
Abstract: During mammalian embryogenesis, de novo hematopoiesis occurs transiently in multiple anatomical sites including the yolk sac, dorsal aorta, and heart tube. A long-unanswered question is whether these local transient hematopoietic mechanisms are essential for embryonic… read more here.
Keywords: endocardially derived; essential valvular; tissue macrophages; derived macrophages ... See more keywords
Studying tissue macrophages in vitro: are iPSC-derived cells the answer?
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-018-0054-y
Abstract: Macrophages are immune cells with important roles in tissue homeostasis, inflammation and pathologies. Hence, macrophage populations represent promising targets for modern medicine. Exploiting the potential of macrophage-targeted therapies will require a thorough understanding of the… read more here.
Keywords: macrophages vitro; tissue specific; tissue macrophages; studying tissue ... See more keywords
Tissue macrophages have a split personality
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.363.6432.1187-j
Abstract: Immunology Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov et al. used single-cell RNA sequencing and fate-mapping of murine lung… read more here.
Keywords: tissue macrophages; science; immunology; split personality ... See more keywords
Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO).
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis and haemostasis"
DOI: 10.1160/th16-07-0553
Abstract: Cell accumulation is a prerequisite for adipose tissue inflammation. The leukocyte integrin Mac-1 (CD11b/CD18, αMβ2) is a classic adhesion receptor critically regulating inflammatory cell recruitment. Here, we tested the hypothesis that a genetic deficiency and… read more here.
Keywords: accumulation; tissue macrophages; diet induced; mac ... See more keywords
Paracrine regulation of adipose tissue macrophages by their neighbors in the micro-environment of obese adipose tissue.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac062
Abstract: Obesity has recently been defined as a chronic low-grade inflammatory disease. Obesity-induced inflammation of adipose tissue (AT) is an essential trigger for insulin resistance (IR) and related metabolic diseases. Although the underlying molecular basis of… read more here.
Keywords: micro environment; tissue macrophages; adipose tissue; obesity ... See more keywords
The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.249037
Abstract: Most tissues harbor a substantial population of resident macrophages. Here we elucidate a functional link between the Slc7a7 cationic amino acid transporter and tissue macrophages. We identified a mutant zebrafish devoid of microglia due to… read more here.
Keywords: amino acid; tissue macrophages; cationic amino; tissue ... See more keywords
Pathogenic role of monocytes/macrophages in large vessel vasculitis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.859502
Abstract: Vasculitis is an autoimmune vascular inflammation with an unknown etiology and causes vessel wall destruction. Depending on the size of the blood vessels, it is classified as large, medium, and small vessel vasculitis. A wide… read more here.
Keywords: large vessel; vasculitis; vessel vasculitis; monocytes macrophages ... See more keywords