Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14545
Abstract: How can tissues generate large numbers of cells, yet keep the divisional load (the number of divisions along cell lineages) low in order to curtail the accumulation of somatic mutations and reduce the risk of… read more here.
Keywords: tissue organization; somatic mutations; divisional load; tissue ... See more keywords
Spatial Statistics for Understanding Tissue Organization
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.832417
Abstract: Interpreting tissue architecture plays an important role in gaining a better understanding of healthy tissue development and disease. Novel molecular detection and imaging techniques make it possible to locate many different types of objects, such… read more here.
Keywords: statistics understanding; tissue organization; understanding tissue; types objects ... See more keywords