Assessment of Safety and Efficacy of Combined Trabectedin and Low-Dose Radiotherapy for Patients With Metastatic Soft-Tissue Sarcomas: A Nonrandomized Phase 1/2 Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2019.6584
Abstract: Importance Active therapeutic combinations, such as trabectedin and radiotherapy, offer potentially higher dimensional response in second-line treatment of advanced soft-tissue sarcomas. Dimensional response can be relevant both for symptom relief and for survival. Objective To… read more here.
Keywords: phase; metastatic soft; soft tissue; radiotherapy ... See more keywords
Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall
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DOI: 10.1002/cam4.70026
Abstract: High‐risk soft tissue sarcomas of the extremities and trunk wall (eSTS), as defined by the Sarculator nomogram, are more likely to benefit from (neo)adjuvant anthracycline‐based therapy compared to low/intermediate‐risk patients. The biology underpinning these differential… read more here.
Keywords: extremities trunk; risk; trunk wall; sarcomas extremities ... See more keywords
Metastatic adult-type non-rhabdomyosarcoma soft tissue sarcomas in children and adolescents: A cohort study from the European paediatric Soft tissue sarcoma Study Group.
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DOI: 10.1002/cncr.34814
Abstract: BACKGROUND Limited data exist on the clinical behavior of pediatric non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) with distant metastases at onset, and a clear standard of care has not yet been defined. METHODS This cohort study… read more here.
Keywords: tissue sarcomas; soft tissue; non rhabdomyosarcoma; tissue ... See more keywords
Clinician's primer for soft tissue sarcomas: Nuances of histologic subtypes
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DOI: 10.1002/cncr.35772
Abstract: Soft tissue sarcomas are a rare group of mesenchymal malignancies, with greater than 100 histologic subtypes. Advancements in understanding these subtypes has enabled histology‐tailored management. This primer describes the workup and management of generalized soft… read more here.
Keywords: oncology; management; tissue sarcomas; soft tissue ... See more keywords
Brazilian consensus on the diagnosis and treatment of extremities soft tissue sarcomas
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DOI: 10.1002/jso.25847
Abstract: Soft tissue sarcomas (STSs) are rare tumors and constitute only 1% of all tumors in adults. Indeed, due to their rarity, most cases in Brazil are not treated according to primary international guidelines. read more here.
Keywords: consensus diagnosis; tissue sarcomas; soft tissue; brazilian consensus ... See more keywords
Fungation in soft tissue sarcomas is associated with poor survival
Sign Up to like & getrecommendations! Published in 2017 at "International Orthopaedics"
DOI: 10.1007/s00264-017-3628-6
Abstract: PurposeWhilst much is known on the multiple variables associated with a poor prognosis in soft tissue sarcomas, little evidence exists on the impact of fungation at the time of presentation. The aim of this study… read more here.
Keywords: poor prognosis; soft tissue; associated poor; tissue sarcomas ... See more keywords
Local recurrence rates of superficial versus deep soft tissue sarcoma
Sign Up to like & getrecommendations! Published in 2024 at "Archives of Orthopaedic and Trauma Surgery"
DOI: 10.1007/s00402-024-05326-1
Abstract: Soft tissue sarcomas are a group of malignancies that commonly occur in the extremities. As deep lesions may exist within the confines of the muscular fascia, we postulate that local recurrence rates are higher for… read more here.
Keywords: local recurrence; recurrence; soft tissue; tissue sarcomas ... See more keywords
Proteomic and Metabolomic Profiling in Soft Tissue Sarcomas
Sign Up to like & getrecommendations! Published in 2022 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-022-00947-3
Abstract: Advances in proteomic and metabolomic technologies have accelerated our understanding of multiple aspects of cancer biology across distinct tumour types. Here we review the current state-of-the-art in the use of proteomics and metabolomics in soft… read more here.
Keywords: tissue sarcomas; proteomic metabolomic; metabolomic profiling; soft tissue ... See more keywords
Prognostic value of neutrophil-to-lymphocyte ratio and other inflammatory markers in patients with high-risk soft tissue sarcomas
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-020-02324-8
Abstract: Background Soft tissue sarcomas (STS) have a high risk of relapse in spite of the use of (neo)adjuvant chemotherapy. In this context, looking for new prognostic biomarkers is an interesting field of research. Our aim… read more here.
Keywords: soft tissue; high risk; ratio; tissue sarcomas ... See more keywords
Overview of malignant soft-tissue sarcomas of the limbs.
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DOI: 10.1016/j.crad.2021.08.011
Abstract: Although soft-tissue masses are common, sarcomas are rare malignant neoplasms showing variable mesenchymal differentiation and can occur at any anatomical site. Limb soft-tissue sarcomas (STS) are rare, but often lethal tumours. Although there are scores… read more here.
Keywords: sarcoma; soft tissue; overview malignant; tissue ... See more keywords
Imaging Response Evaluation after Neoadjuvant Treatment in Soft Tissue Sarcomas: Where Do We Stand?
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2021.103309
Abstract: Soft tissue sarcomas (STS) represent a broad family of rare tumours for which surgery with radiotherapy represents first-line treatment. Recently, neoadjuvant chemo-radiotherapy has been increasingly used in high-risk patients in an effort to reduce surgical… read more here.
Keywords: soft tissue; response; neoadjuvant treatment; treatment ... See more keywords