Not all cancers are created equal: Tissue specificity in cancer genes and pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.01.005
Abstract: Tumors arise through waves of genetic alterations and clonal expansion that allow tumor cells to acquire cancer hallmarks, such as genome instability and immune evasion. Recent genomic analyses showed that the vast majority of cancer… read more here.
Keywords: tissue specificity; tissue; cancer; cell ... See more keywords
Infection patterns and molecular data reveal host and tissue specificity of Posthodiplostomum species in centrarchid hosts
Sign Up to like & getrecommendations! Published in 2018 at "Parasitology"
DOI: 10.1017/s0031182018000306
Abstract: Abstract Posthodiplostomum minimum utilizes a three-host life cycle with multiple developmental stages. The metacercarial stage, commonly known as ‘white grub’, infects the visceral organs of many freshwater fishes and was historically considered a host generalist… read more here.
Keywords: specificity posthodiplostomum; tissue specificity; infection; host ... See more keywords
High-throughput functional analysis of lncRNA core promoters elucidates rules governing tissue specificity.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.242222.118
Abstract: Transcription initiates at both coding and noncoding genomic elements, including mRNA and long noncoding RNA (lncRNA) core promoters and enhancer RNAs (eRNAs). However, each class has a different expression profile with lncRNAs and eRNAs being… read more here.
Keywords: lncrna core; tissue specificity; tissue; core promoters ... See more keywords
Tissue-specificity in cancer: The rule, not the exception
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aaw3472
Abstract: Cancer driver genes exhibit remarkable tissue-specificity We are in the midst of a renaissance in cancer genetics. Over the past several decades, candidate-based targeted sequencing efforts provided a steady stream of information on the genetic… read more here.
Keywords: cancer rule; tissue specificity; tissue; cancer ... See more keywords
A mechanism for the tissue specificity in BAP1 cancer syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Translational cancer research"
DOI: 10.21037/tcr.2019.06.41
Abstract: Cancer predisposition syndromes are caused by inherited mutations in tumor suppressor genes. Remarkably, despite the presence of the faulty tumor suppressor gene in virtually every cell in the body, individuals with a cancer predisposition syndrome… read more here.
Keywords: bap1 cancer; mechanism tissue; tissue specificity; specificity bap1 ... See more keywords
A Pan-cancer Analysis Reveals the Tissue Specificity and Prognostic Impact of Angiogenesis-associated Genes in Human Cancers
Sign Up to like & getrecommendations! Published in 2023 at "Current Bioinformatics"
DOI: 10.2174/1574893618666230518163353
Abstract: Angiogenesis is one of the hallmarks of cancer and can impact the processes of cancer initiation, progression, and response to therapy. Anti-angiogenic therapy is thus an encouraging therapeutic option to treat cancers, but the detailed… read more here.
Keywords: angiogenesis associated; cancer; associated genes; tissue specificity ... See more keywords
Tissue specificity drives protective immunity against Staphylococcus aureus infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.795792
Abstract: Infections caused by Staphylococcus aureus range from mild to severe and frequently recur. Emerging evidence suggests that the site and severity of infection drive the potency of elicited immune responses and susceptibility to recurrent infection.… read more here.
Keywords: pneumonia; infection; staphylococcus aureus; tissue specificity ... See more keywords
OsEUL Lectin Gene Expression in Rice: Stress Regulation, Subcellular Localization and Tissue Specificity
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.00185
Abstract: The Euonymus lectin (EUL) family is a unique group of carbohydrate-binding proteins that is omnipresent in plants. Sequences encoding EUL-related lectins have been retrieved from all completely sequenced plant genomes. The rice (Oryza sativa) genome… read more here.
Keywords: rice; tissue specificity; subcellular localization; stress ... See more keywords
New Drug Development and Clinical Trial Design by Applying Genomic Information Management
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14081539
Abstract: Depending on the patients’ genotype, the same drug may have different efficacies or side effects. With the cost of genomic analysis decreasing and reliability of analysis methods improving, vast amount of genomic information has been… read more here.
Keywords: information; genomic information; tissue specificity; drug ... See more keywords