Partitioning and aggregating cross-tissue and tissue-specific genetic effects to identify gene-trait associations
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49924-4
Abstract: TWAS have shown great promise in extending GWAS loci to a functional understanding of disease mechanisms. In an effort to fully unleash the TWAS and GWAS information, we propose MTWAS, a statistical framework that partitions… read more here.
Keywords: cross tissue; tissue specific; tissue tissue; genetic effects ... See more keywords
Design and Fabrication of a Liver-on-a-chip Reconstructing Tissue-tissue Interfaces
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.959299
Abstract: Despite the rapid advances in the liver-on-a-chip platforms, it remains a daunting challenge to construct a biomimetic liver-on-a-chip for in vitro research. This study aimed to reconstruct the tissue-tissue interfaces based on bilayer microspheres and… read more here.
Keywords: bilayer microspheres; tissue interfaces; tissue tissue; liver chip ... See more keywords