Anti-tissue transglutaminase titers are associated with endoscopic findings and severity of mucosal damage in children with celiac disease
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Pediatrics"
DOI: 10.1007/s00431-020-03770-w
Abstract: We aimed to assess the correlation between clinical findings, serology, endoscopic findings, and histology in children diagnosed with celiac disease. Medical records of children diagnosed with celiac disease (2010–2017) at the Schneider Children’s Hospital were… read more here.
Keywords: mucosal damage; tissue transglutaminase; celiac disease; damage ... See more keywords
Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01070
Abstract: Human tissue transglutaminase (hTG2) is a multifunctional enzyme. It is primarily known for its calcium-dependent transamidation activity that leads to formation of an isopeptide bond between glutamine and lysine residues found on the surface of… read more here.
Keywords: human tissue; targeted covalent; tissue transglutaminase; gtp binding ... See more keywords
Micropipette-tip based immunoassay with electrochemical detection of anti-tissue transglutaminase to diagnose celiac disease using staples and a paper-based platform.
Sign Up to like & getrecommendations! Published in 2019 at "ACS sensors"
DOI: 10.1021/acssensors.9b01096
Abstract: In this work, 1-200 µL polypropylene micropipette tips were used as the platform for performing immunoassays after converting their inner surface on a capture zone for the analyte of interest. We have used a micropipette-tip… read more here.
Keywords: micropipette tip; tissue transglutaminase; platform; detection ... See more keywords
Astrocyte-derived tissue Transglutaminase affects fibronectin deposition, but not aggregation, during cuprizone-induced demyelination
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40995
Abstract: Astrogliosis as seen in Multiple Sclerosis (MS) develops into astroglial scarring, which is beneficial because it seals off the site of central nervous system (CNS) damage. However, astroglial scarring also forms an obstacle that inhibits… read more here.
Keywords: demyelination; cuprizone; deposition aggregation; deposition ... See more keywords
Development of new scaffolds as reversible tissue transglutaminase inhibitors, with improved potency or resistance to glutathione addition.
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DOI: 10.1039/c6md00565a
Abstract: Previous studies within our group have yielded a class of cinnamoyl-based competitive reversible inhibitors for tissue transglutaminase (TG2), with Ki values as low as 1.0 μM (compound CP4d). However, due to the electrophilic nature of… read more here.
Keywords: development new; potency; transglutaminase; new scaffolds ... See more keywords
Reliability of anti-tissue transglutaminase antibodies in children with malnutrition
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2021.1882554
Abstract: Abstract Objectives Serological markers are used in the diagnosis of celiac disease. Among these, the most widely used are tissue transglutaminase antibodies (anti-TG2 antibodies). It has been suggested that the mechanisms that are set in… read more here.
Keywords: transglutaminase antibodies; malnutrition; tissue transglutaminase; celiac disease ... See more keywords
Alternative RNA splicing of leucocyte tissue transglutaminase in coeliac disease
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12659
Abstract: Tissue transglutaminase is a ubiquitous and multifunctional protein that contributes to several processes such as apoptosis/survival, efferocytosis, inflammation and tissue repairing under physiological and pathological conditions. Several activities can be associated with well‐established functional domains;… read more here.
Keywords: transglutaminase; splice variants; disease; tissue transglutaminase ... See more keywords
Rising prevalence of celiac disease is not universal and repeated testing is needed for population screening
Sign Up to like & getrecommendations! Published in 2019 at "United European Gastroenterology Journal"
DOI: 10.1177/2050640618818227
Abstract: Background Recent studies suggest that the prevalence of celiac disease is rising. We previously established the prevalence of celiac disease in healthy blood donors in 2002. Objective The purpose of this study was to examine… read more here.
Keywords: transglutaminase antibodies; prevalence; disease; tissue transglutaminase ... See more keywords
Tissue transglutaminase is involved in the inflammatory processes of active chronic gastritis
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Biological Sciences"
DOI: 10.2298/abs210412026r
Abstract: Since tissue transglutaminase-2 (TG2) can represent a marker of inflammation for some gastrointestinal (GI) diseases, we aimed to evaluate TG2 and inflammatory markers? mucosal content in gastric antrum biopsies to shed light on the histological… read more here.
Keywords: tg2; active chronic; chronic gastritis; gastritis ... See more keywords
Effect of Astaxanthin on Tissue Transglutaminase and Cytoskeletal Protein Expression in Amyloid-Beta Stressed Olfactory Ensheathing Cells: Molecular and Delayed Luminescence Studies
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12030750
Abstract: Astaxanthin, a natural compound of Haematococcus pluvialis, possesses antioxidant, anti-inflammatory, anti-tumor and immunomodulatory activities. It also represents a potential therapeutic in Alzheimer’s disease (AD), that is related to oxidative stress and agglomeration of proteins such… read more here.
Keywords: amyloid beta; effect astaxanthin; tissue transglutaminase; ensheathing cells ... See more keywords
Tissue Transglutaminase but Not Microbial Transglutaminase Is Inhibited by Exogenous Oxidative Substances in Celiac Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042248
Abstract: Enzymatic modification of gliadin peptides by human transglutaminase 2 (TG2) is a central step in celiac disease (CD) pathogenesis. Microbial transglutaminase (mTG) mimics the enzymatic function of TG2 and might play a role in CD.… read more here.
Keywords: tissue transglutaminase; tg2; microbial transglutaminase; celiac disease ... See more keywords