A 3D Tissue-wide Digital Imaging Pipeline for Quantitation of Secreted Molecules Shows Absence of CXCL12 Gradients in Bone Marrow.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2019.10.003
Abstract: Technological limitations have hampered understanding of how individual molecules, including putative stem cell regulators, are distributed throughout tissues and stem cell niches. Here, we report adaptation of the proximity ligation assay (PLA) for large-volume, in… read more here.
Keywords: pipeline; stem cell; tissue wide; cxcl12 ... See more keywords
Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.04.04.487003
Abstract: The generation of a correctly-sized cerebral cortex with all-embracing neuronal and glial cell-type diversity critically depends on faithful radial glial progenitor (RGP) cell proliferation/differentiation programs. Temporal RGP lineage progression is regulated by Polycomb Repressive Complex… read more here.
Keywords: tissue wide; cell; lineage progression; sequential prc2 ... See more keywords
Transcription factor binding site clusters identify target genes with similar tissue-wide expression and buffer against mutations
Sign Up to like & getrecommendations! Published in 2018 at "F1000Research"
DOI: 10.12688/f1000research.17363.2
Abstract: Background: The distribution and composition of cis-regulatory modules composed of transcription factor (TF) binding site (TFBS) clusters in promoters substantially determine gene expression patterns and TF targets. TF knockdown experiments have revealed that TF binding… read more here.
Keywords: expression patterns; binding site; tissue wide; expression ... See more keywords
Tissue-Wide Expression of Genes Related to Vitamin D Metabolism and FGF23 Signaling following Variable Phosphorus Intake in Pigs
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12080729
Abstract: Calcium (Ca) and phosphorus (P) homeostasis is maintained by several regulators, including vitamin D and fibroblast growth factor 23 (FGF23), and their tissue-specific activation and signaling cascades. In this study, the tissue-wide expression of key… read more here.
Keywords: tissue wide; vitamin metabolism; expression; wide expression ... See more keywords