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   Articles with "titanium particle" as a keyword



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Ghrelin Fights Against Titanium Particle-Induced Inflammatory Osteolysis Through Activation of β-Catenin Signaling Pathway

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recommendations! Published in 2019 at "Inflammation"

DOI: 10.1007/s10753-019-01026-w

Abstract: Aseptic loosening is a major complication of prosthetic joint surgery, in which exaggerated inflammation and impaired osteoblastogenesis are detected. Ghrelin is a recently discovered neuropeptide that is closely associated with inflammatory conditions and bone regeneration.… read more here.

Keywords: titanium particle; catenin signaling; particle induced; titanium ... See more keywords
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Protein phosphatase 2A as a new target for downregulating osteoclastogenesis and alleviating titanium particle-induced bone resorption.

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recommendations! Published in 2018 at "Acta biomaterialia"

DOI: 10.1016/j.actbio.2018.04.013

Abstract: Receptor activator of nuclear factor-кB ligand (RANKL)-induced osteoclastogenesis is believed to play a critical role in osteolytic diseases including peri-prosthetic osteolysis (PPO), the primary reason for implant failure and revision surgery. In this study, we… read more here.

Keywords: titanium particle; pp2a; particle induced; resorption ... See more keywords
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Emodin attenuates titanium particle‐induced osteolysis and RANKL‐mediated osteoclastogenesis through the suppression of IKK phosphorylation

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recommendations! Published in 2018 at "Molecular Immunology"

DOI: 10.1016/j.molimm.2018.02.008

Abstract: &NA; Aseptic loosening due to wear particles is a serious challenge for orthopedic surgeons, sabotaging the long‐term success of total joint arthroplasty. The existing treatments for aseptic loosening are still far from satisfactory, necessitating more… read more here.

Keywords: titanium particle; emodin; particle induced; induced osteolysis ... See more keywords
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Forsythiaside inhibited titanium particle-induced inflammation via the NF-κB signaling pathway and RANKL-induced osteoclastogenesis and titanium particle-induced periprosthetic osteolysis via JNK, p38, and ERK signaling pathways

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recommendations! Published in 2019 at "RSC Advances"

DOI: 10.1039/c8ra10007a

Abstract: Forsythiaside can act as a candidate drug for the precaution of implant-associated particle-induced osteolysis. read more here.

Keywords: titanium particle; forsythiaside inhibited; particle induced; particle ... See more keywords
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Cortistatin attenuates titanium particle-induced osteolysis through regulation of TNFR1-ROS-caspase-3 signaling in osteoblasts.

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recommendations! Published in 2022 at "Annals of the New York Academy of Sciences"

DOI: 10.1111/nyas.14774

Abstract: Aseptic loosening is a major complication of prosthetic joint surgery and is associated with impaired osteoblast homeostasis. Cortistatin (CST) is a neuropeptide that protects against inflammatory conditions. In this study, we found that expression of… read more here.

Keywords: cst; titanium particle; induced osteolysis; particle ... See more keywords
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The Dopamine D1 Receptor Attenuates Titanium Particle-Induced Inhibition of Osteogenesis by Activating the Wnt Signaling Pathway

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recommendations! Published in 2023 at "Mediators of Inflammation"

DOI: 10.1155/2023/6331650

Abstract: Periprosthetic osteolysis (PPO), caused by wear particles, has become a major cause of joint replacement failure. Secondary surgery after joint replacement poses a serious threat to public health worldwide. Therefore, determining how to effectively inhibit… read more here.

Keywords: titanium particle; inhibition; particle induced; activating wnt ... See more keywords
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20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-κB Signaling Pathways

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recommendations! Published in 2019 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2018.01538

Abstract: Osteolysis is a principal reason for arthroplasty failure like aseptic loosening induced by Titanium (Ti) particle. It is a challenge for orthopedic surgeons. Recent researches show that 20(S)-protopanaxadiol can inhibit inflammatory cytokine release in vitro.… read more here.

Keywords: titanium particle; particle induced; particle; osteolysis ... See more keywords
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Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.848152

Abstract: Wear debris after total joint arthroplasty can attract the recruitment of macrophages, which release pro-inflammatory substances, triggering the activation of osteoclasts, thereby leading to periprosthetic osteolysis (PPOL) and aseptic loosening. However, the development of pharmacological… read more here.

Keywords: induced osteolysis; osteolysis; titanium particle; particle induced ... See more keywords