Early administration of COVID‐19 convalescent plasma with high titer antibody content by live viral neutralization assay is associated with modest clinical efficacy
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26531
Abstract: The efficacy of COVID‐19 convalescent plasma (CCP) as a treatment for hospitalized patients with COVID‐19 remains somewhat controversial; however, many studies have not evaluated CCP documented to have high neutralizing antibody titer by a highly… read more here.
Keywords: neutralization assay; high titer; live viral; viral neutralization ... See more keywords
In situ enhancement of surfactin biosynthesis in Bacillus subtilis using novel artificial inducible promoters
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26197
Abstract: Surfactin‐family lipopeptides are green biosurfactants with substantial industrial potential. The major problem prohibiting surfactin use is the low titer of the wild producer, Bacillus subtilis. Using transcriptomic analysis, four strong promoters, PgroE, Pcdd, PrplK, and… read more here.
Keywords: inducible promoters; surfactin; promoter; bacillus subtilis ... See more keywords
Titer improvement of milbemycins via coordinating metabolic competition and transcriptional co‐activation controlled by Streptomyces antibiotic regulatory protein family regulator in Streptomyces bingchenggensis
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28044
Abstract: Streptomyces bingchenggensis is a promising producer of milbemycins (MILs), the macrolide pesticide used widely in agriculture. The relationship between different biosynthetic gene clusters (BGCs) and the MIL BGC remains unclear, which hinders the precise metabolic… read more here.
Keywords: titer improvement; metabolic competition; regulatory protein; titer ... See more keywords
Rational engineering in Escherichia coli for high‐titer production of baicalein based on genome‐scale target identification
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28087
Abstract: Baicalein is a bioactive flavonoid isolated from the traditional Chinese medicinal plant, Scutellaria baicalensis Georgi. Microbial synthesis of flavonoids has been intensively developed owing to the eco‐friendly nature of the process. However, the titer of… read more here.
Keywords: rational engineering; engineering escherichia; escherichia coli; identification ... See more keywords
An adaptive modeling approach using spiking-augmentation method to improve chemometric model performance in bioprocess monitoring.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology progress"
DOI: 10.1002/btpr.3349
Abstract: Intensified and continuous processes require fast and robust methods and technologies to monitor product titer for faster analytical turnaround time, process monitoring, and process control. The current titer measurements are mostly offline chromatography-based methods which… read more here.
Keywords: adaptive modeling; titer; model performance; model ... See more keywords
What Goes Up Might Come Down: the Spectacular Spread of an Endosymbiont Is Followed by Its Decline a Decade Later
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Ecology"
DOI: 10.1007/s00248-019-01417-4
Abstract: Facultative, intracellular bacterial symbionts of arthropods may dramatically affect host biology and reproduction. The length of these symbiont-host associations may be thousands to millions of years, and while symbiont loss is predicted, there have been… read more here.
Keywords: symbiont; rickettsia infection; frequency; rickettsia ... See more keywords
Systemic metabolic engineering of Enterobacter aerogenes for efficient 2,3-butanediol production
Sign Up to like & getrecommendations! Published in 2024 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-023-12911-8
Abstract: 2,3-Butanediol (2,3-BDO) is an important gateway molecule for many chemical derivatives. Currently, microbial production is gradually being recognized as a green and sustainable alternative to petrochemical synthesis, but the titer, yield, and productivity of microbial… read more here.
Keywords: titer; systemic metabolic; enterobacter aerogenes; metabolic engineering ... See more keywords
Reducing agents assisted fed-batch fermentation to enhance ABE yields
Sign Up to like & getrecommendations! Published in 2021 at "Energy Conversion and Management"
DOI: 10.1016/j.enconman.2020.113627
Abstract: Abstract Acetone-butanol-ethanol (ABE) fermentation process is a promising bioenergy option amid rising concerns over the environmental impact of fossil fuel usage. However, the commercialization of the ABE process has been marred by challenges of low… read more here.
Keywords: reducing agents; fermentation; abe; fed batch ... See more keywords
P038 Donor specific anti-a titer for abo incompatible (ABOi) living kidney transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Human Immunology"
DOI: 10.1016/j.humimm.2018.07.096
Abstract: To increase the donor options for our active living kidney donor program, candidates who are blood group B may receive a living donor transplant from a non-A1 or non-A1B donor. ABO incompatible donors (ABOi) are… read more here.
Keywords: abo; red cells; donor; living kidney ... See more keywords
Optimized feeding schemes of simultaneous saccharification and fermentation process for high lactic acid titer from sugarcane bagasse
Sign Up to like & getrecommendations! Published in 2018 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2017.11.043
Abstract: Abstract A simultaneous saccharification and fermentation (SSF) process of pretreated sugarcane bagasse by Lactobacillus pentosus was designed and optimized for lactic acid (LA) production. Different feeding schemes in SSF process were studied for their effects… read more here.
Keywords: lactic acid; sugarcane bagasse; saccharification fermentation; process ... See more keywords
Effect of time and titer in convalescent plasma therapy for COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102898
Abstract: The clinical benefit of convalescent plasma for COVID-19 patients is still debated. In this systematic review and meta-analysis, we selected 10 randomized clinical trials (RCTs) and 15 non-randomized studies (total number of patients = 22,591)… read more here.
Keywords: plasma; mortality; covid; convalescent plasma ... See more keywords