Association of Titin Variations With Late-Onset Dilated Cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2021.5890
Abstract: Importance Dilated cardiomyopathy (DCM) is frequently caused by genetic factors. Studies identifying deleterious rare variants have predominantly focused on early-onset cases, and little is known about the genetic underpinnings of the growing numbers of patients… read more here.
Keywords: late onset; titin; onset dcm; dilated cardiomyopathy ... See more keywords
Inhibition of Histone Deacetylase 1 Prevents the Decrease in Titin (Connectin) Content and Development of Atrophy in Rat m. soleus after 3-Day Hindlimb Unloading.
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-020-04907-5
Abstract: We studied the effect of histone deacetylase 1 (HDAC1) inhibition on titin content and expression of TTN gene in rat m. soleus after 3-day gravitational unloading. Male Wistar rats weighing 210±10 g were randomly divided… read more here.
Keywords: titin; day hindlimb; inhibition; day ... See more keywords
Calcium-dependent titin–thin filament interactions in muscle: observations and theory
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Muscle Research and Cell Motility"
DOI: 10.1007/s10974-019-09540-y
Abstract: Gaps in our understanding of muscle mechanics demonstrate that the current model is incomplete. Increasingly, it appears that a role for titin in active muscle contraction might help to fill these gaps. While such a… read more here.
Keywords: titin; n2a titin; muscle; titin thin ... See more keywords
Special issue on titin and its binding proteins in striated muscle
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0270-x
Abstract: Titin is the largest known muscle protein with a megaDalton molecular weight and a contour length greater than one micron. One molecule of titin spans half a sarcomere connecting both the M-line and the Z-disc.… read more here.
Keywords: protein; titin; issue; muscle ... See more keywords
An historical perspective of the discovery of titin filaments –Part 2
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0393-0
Abstract: In 2017, a Special Issue of Biophysical Reviews was devoted to “Titin and Its Binding Partners. The issue contained a review: “An historical perspective of the discovery of titin filaments” by dos Remedios and Gilmour… read more here.
Keywords: titin; historical perspective; titin filaments; discovery ... See more keywords
Mechanically Unfolded Titin Immunoglobulin Domains Refold Faster and More Accurately in Presence of Chaperone Alpha-B-Crystallin
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.263
Abstract: The spring region of the giant muscle protein titin contains many immunoglobulin-like (Ig) domains, which unfold and refold under low (physiological) stretch forces. Small heat shock proteins such as alphaB-crystallin (aBC) translocate under physiological or… read more here.
Keywords: refolded fraction; titin; presence; abc ... See more keywords
Emulating Titin by a Multidomain DNA Structure.
Sign Up to like & getrecommendations! Published in 2022 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.2c00585
Abstract: Titin, a giant protein containing multiple tandem domains, is essential in maintaining the superior mechanical performance of muscle. The consecutive and reversible unfolding and refolding of the domains are crucial for titin to serve as… read more here.
Keywords: multidomain dna; dna; titin; titin multidomain ... See more keywords
Inverse changes in plasma tetranectin and titin levels in patients with type 2 diabetes mellitus: a potential predictor of acute myocardial infarction?
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.141
Abstract: An early intervention using biomarkers to predict acute myocardial infarction (AMI) will effectively reduce global heart attack incidence, particularly among high-risk patients with type 2 diabetes mellitus (T2DM). This study attempted to identify potential biomarkers… read more here.
Keywords: patients type; titin; myocardial infarction; type diabetes ... See more keywords
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15465-9
Abstract: Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins in their natural environment remains inaccesible to conventional… read more here.
Keywords: titin; genetic cassette; cassette mechanical; halotag tev ... See more keywords
Stretching Single Titin Molecules from Failing Human Hearts Reveals Titin's Role in Blunting Cardiac Kinetic Reserve.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvz043
Abstract: AIMS Heart failure patients commonly experience symptoms primarily during elevated heart rates, as a result of physical activities or stress. A main determinant of diastolic passive tension, the elastic sarcomeric protein titin, has been shown… read more here.
Keywords: human hearts; titin; heart; role ... See more keywords
Evaluation of cardiac titin expression after long-term exercise in a rat model
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3127
Abstract: The main role of the giant elastic protein titin is to provide passive stiffness to striated (i.e. cardiac and skeletal) muscles. The adult cardiac muscle contains two titin isoforms: the more compliant N2BA and the… read more here.
Keywords: titin; heart; long term; n2ba n2b ... See more keywords