Evaluation of Methylphenidate Safety and Maximum-Dose Titration Rationale in Attention-Deficit/Hyperactivity Disorder: A Meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2019.0905
Abstract: Importance Evidence on the titration of stimulant medications for attention-deficit/hyperactivity disorder (ADHD) is lacking. However, this lack of evidence has not prevented medication guidelines from specifying apparently arbitrary dose limitations, which could discourage clinicians from… read more here.
Keywords: titration; dose titration; disorder; maximum dose ... See more keywords
The Drug Titration Paradox: Correlation of More Drug With Less Effect in Clinical Data
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2162
Abstract: While analyzing clinical data where an anesthetic was titrated based on an objective measure of drug effect, we observed paradoxically that greater effect was associated with lesser dose. With this study we sought to find… read more here.
Keywords: titration paradox; titration; effect; drug ... See more keywords
The Drug Titration Paradox Updated and Reinterpreted: With Perfect Titration, Dose and Effect Will Be Uncorrelated
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3673
Abstract: The drug titration paradox is a clinical observation at a population level whereby patients receiving a high dose of medication appear to have a lower‐than‐average clinical effect, and patients receiving a low dose of medication… read more here.
Keywords: drug titration; titration; dose effect; paradox ... See more keywords
Left ventricular output indices and sacubitril/valsartan titration: role of stroke volume index.
Sign Up to like & getrecommendations! Published in 2022 at "ESC heart failure"
DOI: 10.1002/ehf2.13891
Abstract: AIMS This study aims to investigate the role of echocardiographically determined left ventricular output indices on sacubitril/valsartan titration in a cohort of outpatients with heart failure and reduced ejection fraction (HFrEF). METHODS AND RESULTS We… read more here.
Keywords: volume index; sacubitril valsartan; titration; stroke volume ... See more keywords
Titration of medications and outcomes in multi‐ethnic heart failure cohorts (with reduced ejection fraction) from Singapore and New Zealand
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14275
Abstract: We investigated titration patterns of angiotensin‐converting enzyme inhibitors (ACEis)/angiotensin receptor blockers (ARBs) and beta‐blockers, quality of life (QoL) over 6 months, and associated 1 year outcome [all‐cause mortality/heart failure (HF) hospitalization] in a real‐world population… read more here.
Keywords: heart failure; titration; ejection fraction; heart ... See more keywords
Heart failure treatment up‐titration and outcome and age: an analysis of BIOSTAT‐CHF
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1799
Abstract: Several studies have shown that older patients with heart failure with reduced ejection fraction (HFrEF) are undertreated. The aim of this study was to evaluate the association of up‐titration of angiotensin‐converting enzyme inhibitors (ACEI), angiotensin… read more here.
Keywords: heart; titration; age; heart failure ... See more keywords
The time has finally come to prioritize drug initiation before dose titration for patients with heart failure and reduced ejection fraction
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1936
Abstract: Since 1980, treatment of heart failure (HF) with reduced ejection fraction (HFrEF) has steadily evolved to stepwise combination of angiotensin-converting enzyme inhibitor (ACEi)/angiotensin receptor blocker (ARB) inhibition, beta-blockade (BB), and mineralocorticoid receptor antagonism (MRA).1 This… read more here.
Keywords: heart; initiation; titration; heart failure ... See more keywords
Iodide reaction times of peroxyhemiacetals (PHAs) in the peroxide value titration; implications for the testing of citrus oils
Sign Up to like & getrecommendations! Published in 2019 at "Flavour and Fragrance Journal"
DOI: 10.1002/ffj.3542
Abstract: Limonene and linalool are major components in many essential oils, and both may autoxidize under certain conditions to form terpene hydroperoxides (THPs), which are reported to be sensitizers that may cause allergic contact dermatitis. This… read more here.
Keywords: titration; peroxyhemiacetals phas; iodide reaction; peroxide value ... See more keywords
Comparison of open cell and single‐step total alkalinity titration methods and implications for organic alkalinity
Sign Up to like & getrecommendations! Published in 2025 at "Limnology and Oceanography: Methods"
DOI: 10.1002/lom3.70002
Abstract: An open question in marine carbon chemistry is if organic alkalinity (or some other unidentified species) is present in non‐negligible quantities in the open ocean. If organic alkalinity is indeed present, different methods for total… read more here.
Keywords: open cell; titration; alkalinity; single step ... See more keywords
Solution to titration endpoint challenge
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01800-7
Abstract: This challenge invites us to think about the endpoint estimates in acid-base titration [1]. The purpose of titration is to establish the amount of a substance present in solution by chemically reacting that substance with… read more here.
Keywords: endpoint; titration endpoint; titration; challenge ... See more keywords
Electrical impedance tomography for PEEP titration in ARDS patients: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Monitoring and Computing"
DOI: 10.1007/s10877-025-01266-2
Abstract: To assess the efficacy of electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration in improving outcomes for patients with acute respiratory distress syndrome (ARDS). A systematic review and meta-analysis was conducted following Preferred Reporting… read more here.
Keywords: titration; electrical impedance; eit guided; impedance tomography ... See more keywords