Aptamer-Based Sandwich Assay for Measurement of Thymidine Kinase 1 in Serum of Cancerous Patients.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01284
Abstract: Thymidine kinase 1 (TK1) is traditionally a serum biomarker that is elevated in the early stages of malignancies. The diagnostic and prognostic role of TK1 for screening and monitoring human malignancies has recently been investigated.… read more here.
Keywords: sandwich assay; cancerous patients; tk1; aptamer ... See more keywords
Abstract 543: Monoclonal antibodies against thyimidine kinase 1 for the immunotargeting of lung and breast cancer cells, a preclinical evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-543
Abstract: This study explores the potential therapeutic use of monoclonal antibodies against the tumor proliferation biomarker TK1 for the immunotargeting of lung and breast cancer cells. Recent clinical trials have led to the approval of monoclonal… read more here.
Keywords: cancer; monoclonal antibodies; tk1; lung breast ... See more keywords
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008439
Abstract: Metabolic alterations that are critical for cancer cell growth and metastasis are one of the key hallmarks of cancer. Here, we show that thymidine kinase 1 (TK1) is significantly overexpressed in tumor samples from lung… read more here.
Keywords: tk1; expression; growth metastatic; cancer ... See more keywords
Analytical and clinical characterization of an optimized dual monoclonal sandwich ELISA for the quantification of thymidine kinase 1 (TK1) protein in human blood samples
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0275444
Abstract: Thymidine Kinase 1 (TK1) plays an important role in DNA precursor synthesis and serum TK1 activity has been used as a biomarker for prognosis and therapy monitoring of different malignancies. AroCell has developed a dual… read more here.
Keywords: 210 elisa; dual monoclonal; thymidine kinase; tk1 ... See more keywords
Serum Concentration of Thymidine Kinase 1 (TK1) as a Tumor Marker in Soft Tissue Sarcomas
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DOI: 10.21873/anticanres.15623
Abstract: Background/Aim: The aim of this prospective study was to determine whether serum Thymidine kinase –1 (TK1) could serve as a tumor marker in soft tissue sarcomas (STS). Patients and Methods: A total of 48 patients… read more here.
Keywords: kinase tk1; tumor marker; thymidine kinase; tk1 ... See more keywords
Assessing the Potential Prognostic and Immunological Role of TK1 in Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.778850
Abstract: Background: It has been reported that thymidine kinase 1 (TK1) was up-regulated in multiple malignancies and participated in the regulation of tumor malignant behavior. However, its specific role in prostate cancer (PCa) remains unclear. Methods:… read more here.
Keywords: prostate cancer; pca patients; pca; expression ... See more keywords