Genistein‐induced DNA damage is repaired by nonhomologous end joining and homologous recombination in TK6 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27082
Abstract: Genistein (GES), a phytoestrogen, has potential chemopreventive and chemotherapeutic effects on cancer. The anticancer mechanism of GES may be related with topoisomerase II associated DNA double‐strand breaks (DSBs). However, the precise molecular mechanism remains elusive.… read more here.
Keywords: end joining; dna damage; tk6; induced dna ... See more keywords
SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2'-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00213
Abstract: DNA-protein cross-links (DPCs) are generated by internal factors such as cellular aldehydes that are generated during normal metabolism and external factors such as environmental mutagens. A nucleoside analog, 5-aza-2'-deoxycytidine (5-azadC), is randomly incorporated into the… read more here.
Keywords: tdp1 tdp2; tk6; dpcs; dnmt1 dpcs ... See more keywords