PARP‐1 modulates the expression of miR‐223 through histone acetylation to involve in the hydroquinone‐induced carcinogenesis of TK6 cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23142
Abstract: The upstream regulators of microRNAs were rarely reported. Hydroquinone (HQ) is the main metabolite of benzene, one of the important environmental factors contributing to leukemia and lymphoma. In HQ‐induced malignant transformed TK6 (TK6‐HT) cells, the… read more here.
Keywords: expression mir; tk6 cells; hydroquinone; mir 223 ... See more keywords
Genistein‐induced DNA damage is repaired by nonhomologous end joining and homologous recombination in TK6 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27082
Abstract: Genistein (GES), a phytoestrogen, has potential chemopreventive and chemotherapeutic effects on cancer. The anticancer mechanism of GES may be related with topoisomerase II associated DNA double‐strand breaks (DSBs). However, the precise molecular mechanism remains elusive.… read more here.
Keywords: end joining; dna damage; tk6; induced dna ... See more keywords
Cytotoxic and genotoxic effects of e-liquids and their potential associations with nicotine, menthol and phthalate esters.
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DOI: 10.1016/j.chemosphere.2020.126153
Abstract: In this study, we determined DNA damage and chromosome breakage (indicators of genotoxicity) and cell viability (an indicator of cytotoxicity) in human lymphoblastoid TK6 and Chinese hamster ovary (CHO) cells treated with 33 e-liquids using… read more here.
Keywords: tk6 cells; dna damage; cell viability; damage ... See more keywords
Regulatory loop between lncRNA FAS-AS1 and DNMT3b controls FAS expression in hydroquinone-treated TK6 cells and benzene-exposed workers.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.114147
Abstract: Hydroquinone (HQ), one of the main metabolites of benzene, is a well-known human leukemogen. However, the specific mechanism of how benzene or HQ contributes to the development of leukemia is unknown. In a previous study,… read more here.
Keywords: tk6 cells; dnmt3b; expression; fas as1 ... See more keywords
High-content imaging analyses of γH2AX-foci and micronuclei in TK6 cells elucidated genotoxicity of chemicals and their clastogenic/aneugenic mode of action
Sign Up to like & getrecommendations! Published in 2019 at "Genes and Environment"
DOI: 10.1186/s41021-019-0117-8
Abstract: BackgroundThe in vitro micronucleus (MN) test is an important component of a genotoxicity test battery that evaluates chemicals. Although the standard method of manually scoring micronucleated (MNed) cells by microscope is a reliable and standard… read more here.
Keywords: tk6 cells; mode; h2ax foci; mode action ... See more keywords