The TKFC Ala185Thr variant, reported as ‘null’ for fructose metabolism, is fully active as triokinase
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DOI: 10.1002/1873-3468.14309
Abstract: TKFC‐encoded triokinase catalyses glyceraldehyde phosphorylation in fructose metabolism and favours lipogenesis in mice. In Tkfc knockouts or knockdowns, fructose oxidation predominates over lipogenesis. The highly prevalent human variant Ala185Thr‐Triokinase/FMN cyclase (TKFC) has been reported to… read more here.
Keywords: reported null; tkfc; triokinase; null fructose ... See more keywords