In vitro UGT1A1 inhibition by tyrosine kinase inhibitors and association with drug-induced hyperbilirubinemia
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3665-x
Abstract: PurposeHyperbilirubinemia has been observed in patients treated with tyrosine kinase inhibitor (TKI) drugs. Therefore, it would be beneficial to understand whether there is a relationship between inhibition of uridine-5′-diphosphate glucuronosyltransferase (UGT) 1A1 activity and observed… read more here.
Keywords: tki drugs; inhibition; hyperbilirubinemia; vitro ugt1a1 ... See more keywords
Facilitated Transport of EGFR Inhibitors Plays an Important Role in Their Cellular Uptake.
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DOI: 10.1021/acs.analchem.3c04242
Abstract: Epidermal growth factor receptor (EGFR) is a transmembrane protein commonly targeted by tyrosine kinase inhibitors (TKIs) as a front-line therapy for patients with many cancers including nonsmall cell lung cancer (NSCLC). Effective treatment requires efficient… read more here.
Keywords: egfr inhibitors; role; cellular uptake; transport egfr ... See more keywords