Clinical utility of plasma-based digital next-generation sequencing in oncogene-driven non-small-cell lung cancer patients with tyrosine kinase inhibitor resistance.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.05.032
Abstract: OBJECTIVES Resistance to tyrosine-kinase inhibitors (TKIs) is a clinical challenge in patients with oncogene-driven non-small-cell lung cancers (NSCLC). We have analyzed the utility of next-generation sequencing (NGS) of cell-free circulating tumor DNA (ctDNA) to impact… read more here.
Keywords: oncogene driven; generation; lung; resistance ... See more keywords
Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Cancer"
DOI: 10.1038/bjc.2017.292
Abstract: Background:Tyrosine kinase inhibitors (TKIs) have demonstrated clinical benefits in the treatment of several tumour types. However, the emergence of TKI resistance restricts the therapeutic effect. This study uses non-small cell lung cancer (NSCLC) to explore… read more here.
Keywords: tki resistance; resistance; akt foxm1; cancer ... See more keywords
Abstract B114: Progesterone receptor membrane component 1 is a candidate key molecule involved EGFR-TKI resistance in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-b114
Abstract: To overcome the resistance of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in non-small cell lung cancer, the mechanism clarification and novel molecular target development are urgently required. From this viewpoint, we previously identified… read more here.
Keywords: treatment; resistance; tki resistance; pc9 ... See more keywords
Cobll1: A new player in CML
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DOI: 10.18632/oncotarget.21705
Abstract: Chronic myeloid leukemia (CML) is a malignant cancer derived from hematopoietic stem cells. CML is induced by an oncogenic BCR-ABL1 fusion protein, which has constitutive tyrosine kinase activity. The BCR-ABL1 fusion protein is produced from… read more here.
Keywords: cml; tki resistance; cobll1; resistance ... See more keywords
Involvement of the TNF-α Pathway in TKI Resistance and Suggestion of TNFR1 as a Predictive Biomarker for TKI Responsiveness in Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Korean Medical Science"
DOI: 10.3346/jkms.2020.35.e31
Abstract: Background Mechanism and predictive biomarkers for tyrosine kinase inhibitor (TKI) resistance of advanced clear cell renal cell carcinoma (ccRCC) have not been fully evaluated. Methods We performed gene expression profiling on samples from an acquired… read more here.
Keywords: cell renal; tki resistance; clear cell; tki ... See more keywords
Analysis of the lncRNA–miRNA–mRNA Network Reveals a Potential Regulatory Mechanism of EGFR-TKI Resistance in NSCLC
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.851391
Abstract: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are widely used for patients with EGFR-mutated lung cancer. Despite its initial therapeutic efficacy, most patients eventually develop drug resistance, which leads to a poor prognosis in… read more here.
Keywords: egfr tki; resistance; target mrnas; tki resistance ... See more keywords
EMT-Mediated Acquired EGFR-TKI Resistance in NSCLC: Mechanisms and Strategies
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DOI: 10.3389/fonc.2019.01044
Abstract: Acquired resistance inevitably limits the curative effects of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), which represent the classical paradigm of molecular-targeted therapies in non-small-cell lung cancer (NSCLC). How to break such a bottleneck… read more here.
Keywords: tki resistance; resistance; emt mediated; mediated acquired ... See more keywords
Is ICI-based therapy better than chemotherapy for metastatic NSCLC patients who develop EGFR-TKI resistance? A real-world investigation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.920047
Abstract: Purpose To evaluate the outcomes of immune checkpoint inhibitor (ICI)-based treatments versus classical chemotherapy for metastatic non-small cell lung cancer (NSCLC) patients who develop epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance and to… read more here.
Keywords: based therapy; egfr tki; tki resistance; ici based ... See more keywords