Pulsatile high-dose treatment with antiangiogenic tyrosine kinase inhibitors improves clinical antitumor activity
Sign Up to like & getrecommendations! Published in 2017 at "Angiogenesis"
DOI: 10.1007/s10456-017-9555-8
Abstract: Angiogenesis comprises one of the core hallmarks of cancer, essential for tumor establishment and growth. Elucidating the components of the angiogenic molecular pathway led to the identification of the crucial signaling axis of vascular endothelial… read more here.
Keywords: treatment; tkis; activity; tyrosine kinase ... See more keywords
Hype or hope - Can combination therapies with third-generation EGFR-TKIs help overcome acquired resistance and improve outcomes in EGFR-mutant advanced/metastatic NSCLC?
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2021.103454
Abstract: Three generations of epidermal growth factor receptor - tyrosine kinase inhibitors (EGFR-TKIs) have been developed for treating advanced/metastatic non-small cell lung cancer (NSCLC) patients harboring EGFR-activating mutations, while a fourth generation is undergoing preclinical assessment.… read more here.
Keywords: advanced metastatic; combination; egfr tkis; resistance ... See more keywords
Application of liquid biopsy-based targeted capture sequencing analysis to improve the precision treatment of non-small cell lung cancer by tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open Respiratory Research"
DOI: 10.1136/bmjresp-2021-001154
Abstract: Background Targeted therapy of patients with non-small cell lung cancer (NSCLC) who harbour sensitising mutations by tyrosine kinase inhibitors (TKIs) has been found more effective than traditional chemotherapies. However, target genes status (eg, epidermal growth… read more here.
Keywords: cell; capture sequencing; tkis; treatment ... See more keywords
Tyrosine Kinase Inhibitor–Associated Platelet Dysfunction: Does This Need to Have a Significant Clinical Impact?
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Applied Thrombosis/Hemostasis"
DOI: 10.1177/1076029619866925
Abstract: The management of chronic myeloid leukemia (CML) entirely changed after the emergence of tyrosine kinase inhibitors (TKIs). In the era of TKIs, the 10-year overall survival now exceeds 80%, and the prevalence of patients receiving… read more here.
Keywords: platelet function; platelet functions; platelet dysfunction; tkis ... See more keywords
ABL Tyrosine Kinase Inhibitors (TKIs) Are Associated with Increased Rho-Associated Kinase (ROCK) Activity That May Contribute to Vascular Toxicity in Patients with Chronic Myeloid Leukemia (CML)
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-111201
Abstract: Introduction The use of 2nd or 3rd generation ABL TKIs in patients with CML is associated with vascular toxicity, including peripheral arterial occlusive disease and cardiovascular and cerebrovascular events. However, Imatinib, a 1st generation TKI,… read more here.
Keywords: rock activity; patients receiving; leukocyte rock; tkis ... See more keywords
Pulmonary complications of tyrosine kinase inhibitors in myeloproliferative disorders
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.02653-2020
Abstract: Life has changed for patients with chronic myeloid leukaemia (CML) since the introduction of breakpoint cluster region–Abelson (Bcr-Abl) tyrosine kinase inhibitors (TKIs) in the late 1990s. Before the era of the TKIs began, the 5-year… read more here.
Keywords: kinase inhibitors; pulmonary complications; bcr abl; tkis ... See more keywords
Microwave ablation combined with EGFR-TKIs versus only EGFR-TKIs in advanced NSCLC patients with EGFR-sensitive mutations
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18083
Abstract: We conducted this retrospective study to investigate whether microwave ablation (MWA) of primary tumor sites plus epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) could improve survival in advanced non small cell lung cancer (NSCLC) with… read more here.
Keywords: egfr tkis; egfr sensitive; sensitive mutations; microwave ablation ... See more keywords
Clinical outcomes of WBRT plus EGFR-TKIs versus WBRT or TKIs alone for the treatment of cerebral metastatic NSCLC patients: a meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19054
Abstract: Whether WBRT plus EGFR-TKIs has a greater survival benefit than EGFR-TKIs alone or WBRT alone remains controversial in NSCLC patients with multiple brain metastases. To rectify this, we conducted a systematic meta-analysis based on 9… read more here.
Keywords: plus egfr; egfr tkis; wbrt plus; tkis alone ... See more keywords
Extended therapy breaks from VEGFR TKI therapy in renal cell carcinoma: Sometimes less is more
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23005
Abstract: The treatment landscape of metastatic renal cell carcinoma (mRCC) dramatically changed with the introduction of vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) [1]. Despite major advances in the field of immunotherapy, TKIs… read more here.
Keywords: mrcc; treatment breaks; treatment; vegfr tki ... See more keywords
Comparison of Different EGFR Gene Mutation Status in Patients with Metastatic Non-Small Lung Cancer After First-Line EGFR-TKIs Therapy and Analyzing Its Relationship with Efficacy and Prognosis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Management and Research"
DOI: 10.2147/cmar.s329900
Abstract: Purpose The purpose of this study is to compare the different EGFR mutation status in patients with metastatic non-small cell lung cancer (NSCLC) after first-line EGFR-TKIs therapy and analyze its relationship with efficacy and prognosis.… read more here.
Keywords: tkis; egfr mutation; mutation status; different egfr ... See more keywords
Comparison of the Incidence Rate of Radiation Pneumonitis Observed in Patients with Advanced Lung Adenocarcinoma Treated with Simultaneous Thoracic Radiotherapy and 1G/2G/3G EGFR-TKIs.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer management and research"
DOI: 10.2147/cmar.s404874
Abstract: Purpose The present study aimed to evaluate the incidence rate of radiation pneumonitis (RP) in patients with advanced lung adenocarcinoma treated with first-generation (1G), second-generation (2G), or third-generation (3G) epidermal growth factor receptor tyrosine kinase… read more here.
Keywords: egfr tkis; patients advanced; advanced lung; incidence rate ... See more keywords