Hypersensitivity of mouse embryonic fibroblast cells defective for DNA polymerases η, ι and κ to various genotoxic compounds: Its potential for application in chemical genotoxic screening.
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DOI: 10.1016/j.dnarep.2017.11.006
Abstract: Genotoxic agents cause modifications of genomic DNA, such as alkylation, oxidation, bulky adduct formation, and strand breaks, which potentially induce mutations and changes to the structure or number of genes. Majority of point mutations are… read more here.
Keywords: dna; tko cells; dna polymerases; mouse embryonic ... See more keywords