Significance of the Tks4 scaffold protein in bone tissue homeostasis
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DOI: 10.1038/s41598-019-42250-6
Abstract: The main driver of osteoporosis is an imbalance between bone resorption and formation. The pathogenesis of osteoporosis has also been connected to genetic alterations in key osteogenic factors and dysfunction of bone marrow mesenchymal stem/stromal… read more here.
Keywords: homeostasis; bone tissue; tks4; tks4 scaffold ... See more keywords
A Novel Cell-Based Model for a Rare Disease: The Tks4-KO Human Embryonic Stem Cell Line as a Frank-Ter Haar Syndrome Model System
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DOI: 10.3390/ijms23158803
Abstract: Tyrosine kinase substrate with four SH3 domains (Tks4) scaffold protein plays roles in cell migration and podosome formation and regulates systemic mechanisms such as adult bone homeostasis and adipogenesis. Mutations in the Tks4 gene (SH3PXD2b)… read more here.
Keywords: cell; stem cell; embryonic stem; tks4 ... See more keywords