Crohn's disease‐associated mucosal factors regulate the expression of TNF‐like cytokine 1A and its receptors in primary subepithelial intestinal myofibroblasts and intestinal epithelial cells
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DOI: 10.1016/j.trsl.2016.08.007
Abstract: &NA; Intestinal subepithelial myofibroblasts (SEMFs) exert a profibrotic role in Crohn's disease (CD). Tumor necrosis factor‐like cytokine 1A (TL1A) and its receptors, death‐domain receptor 3 (DR3) and decoy receptor 3 (DcR3), are mucosal factors with… read more here.
Keywords: epithelial cells; intestinal epithelial; like cytokine; tl1a ... See more keywords
Inflammation independent TL1A-mediated Intestinal Fibrosis is Dependent on the Gut Microbiome
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DOI: 10.1038/s41385-018-0055-y
Abstract: Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease (IBD), modulating the location and severity of intestinal inflammation and fibrosis. TL1A expression is increased in inflamed gut mucosa and associated with… read more here.
Keywords: intestinal fibrosis; fibrosis; tl1a; tl1a mediated ... See more keywords
DEVELOPMENT AND CHARACTERIZATION OF SL-325, A DR3-TARGETED, ANTAGONISTIC ANTIBODY FOR THE TREATMENT OF IBD
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DOI: 10.1053/j.gastro.2025.01.079
Abstract: Commonly known as Death Receptor 3 (DR3), tumor necrosis factor receptor super family 25 (TNFRSF25) is a member of the TNFR super family that binds to soluble and cell-surface expressed forms of its monogamous ligand,… read more here.
Keywords: dr3; treatment; ibd; tl1a ... See more keywords
P911 Development and Characterization of SPY002, a Novel Extended Half-life Monoclonal Antibody Drug Candidate Targeting TL1A for the Treatment of IBD
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.1041
Abstract: Tumor necrosis factor (TNF)-like ligand 1A (TL1A) mediates a broad spectrum of pro-inflammatory and fibrotic effects and is implicated in the pathogenesis of several immunologic disorders. Blockade of the interaction of TL1A with its cognate… read more here.
Keywords: extended half; tl1a; spy002; spy002 novel ... See more keywords
P0789 Combined inhibition of TL1A and integrin β7 is superior to either monotherapy in mouse models of colitis and coadministration of SPY001 and SPY002 demonstrates no drug-drug effects on exposure in non-human primates
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.0963
Abstract: Advanced treatments for IBD typically have placebo-adjusted clinical remission rates of only 10 to 25%. The combined use of targeted biologic agents could break through this efficacy ceiling while avoiding the risks associated with broad… read more here.
Keywords: tl1a; combination; anti; drug ... See more keywords
Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion
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DOI: 10.1371/journal.pone.0173460
Abstract: TNF-like 1A (TL1A) is a cytokine belonging to the TNF superfamily that promotes inflammation in autoimmune diseases. Inhibiting the interaction of TL1A with the endogenous death-domain receptor 3 (DR3) offers a therapeutic approach for treating… read more here.
Keywords: tl1a induced; dr3; tl1a; directed evolution ... See more keywords
TL1A mediates fibroblast-like synoviocytes migration and Indian Hedgehog signaling pathway via TNFR2 in patients with rheumatoid arthritis
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DOI: 10.1684/ecn.2018.0405
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central… read more here.
Keywords: signaling pathway; hedgehog signaling; indian hedgehog; tl1a ... See more keywords
A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macrophages, and Lymphocytes Induces Adipose Tissue Dysfunction Downstream of E2F1 in Human Obesity
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DOI: 10.2337/db19-1231
Abstract: Elevated expression of E2F1 in adipocyte fraction of human visceral adipose tissue (hVAT) associates with a poor cardiometabolic profile. We hypothesized that beyond directly activating autophagy and MAP3K5 (ASK)–MAP kinase signaling, E2F1 governs a distinct… read more here.
Keywords: tl1a; dysfunction; tissue; e2f1 ... See more keywords
Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review
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DOI: 10.3389/fimmu.2022.891328
Abstract: TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in different immune cell, such as monocyte, macrophage, dendritic cell, T cell and non-immune cell, for example, synovial fibroblast, endothelial… read more here.
Keywords: tl1a; cell; inflammatory autoimmune; autoimmune diseases ... See more keywords
Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis
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DOI: 10.3389/fimmu.2024.1340467
Abstract: Background Interleukin (IL)-17-producing γδT (γδT17) cells mediate inflammatory responses in barrier tissues. Dysregulated γδT17 cell activation can lead to the overproduction of IL-17 and IL-22 and the development of inflammatory diseases, including psoriasis. IL-23 and… read more here.
Keywords: t17 cells; tl1a; cell activation; cell ... See more keywords