Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.052
Abstract: Mammalian Transducin-like enhancer of split (TLE) confer global repression of numerous target genes in conjunction with a myriad of DNA-binding repressors. These factors have a major role in the regulation of multiple signal transduction pathways.… read more here.
Keywords: tle3; differential functions; tle1 tle3; phosphorylation site ... See more keywords
Pan-Cancer Analysis of TLE3 Revealed Its Value in Tumor Microenvironment and Prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/4085770
Abstract: Background Transducin-like enhancer of split 3 (TLE3), a member of the TLE gene family, is related to tumor genesis and progression. However, whether TLE3 played a crucial role in the whole pan-cancer remained unknown. Methods… read more here.
Keywords: tle3; tumor; pan cancer; tumor microenvironment ... See more keywords
TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3133
Abstract: Breast cancer subtypes and their phenotypes parallel different stages of the mammary epithelial cell developmental hierarchy. Discovering mechanisms that control lineage identity could provide novel avenues for mitigating disease progression. Here we report that the… read more here.
Keywords: tle3; luminal breast; breast; breast cancer ... See more keywords