Differential requirements for Tousled-like kinases 1 and 2 in mammalian development
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.108
Abstract: The regulation of chromatin structure is critical for a wide range of essential cellular processes. The Tousled-like kinases, TLK1 and TLK2, regulate ASF1, a histone H3/H4 chaperone, and likely other substrates, and their activity has… read more here.
Keywords: mammalian development; tlk2; like kinases; tousled like ... See more keywords
Molecular basis of Tousled-Like Kinase 2 activation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04941-y
Abstract: Tousled-like kinases (TLKs) are required for genome stability and normal development in numerous organisms and have been implicated in breast cancer and intellectual disability. In humans, the similar TLK1 and TLK2 interact with each other… read more here.
Keywords: tlk2; like kinase; kinase; activation ... See more keywords
Case report: A novel TLK2 variant with a neuropsychiatric phenotype from a Chinese family
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2024.1419027
Abstract: Background Tousled-like kinase 2 (TLK2) gene variant-related neurodevelopmental disorder was recently described. The haploinsufficiency of TLK2 was considered the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype. So far, only four studies,… read more here.
Keywords: neuropsychiatric phenotype; chinese family; tlk2; variant ... See more keywords