Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling
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DOI: 10.1002/glia.23208
Abstract: The complement 3a receptor (C3aR1) participates in microglial signaling under pathological conditions and was recently shown to be activated by the neuropeptide TLQP‐21. We previously demonstrated that TLQP‐21 elicits hyperalgesia and contributes to nerve injury‐induced… read more here.
Keywords: tlqp; dorsal horn; complement receptor; horn microglia ... See more keywords
Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21
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DOI: 10.1371/journal.pone.0221517
Abstract: TLQP-21, a peptide encoded by the highly conserved vgf gene, is expressed in neuroendocrine cells and has been the most prominent VGF-derived peptide studied in relation to control of energy balance. The recent discovery that… read more here.
Keywords: vgf derived; siberian hamsters; tlqp; derived peptide ... See more keywords
TLQP-21 is a low potency partial C3aR activator on human primary macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1086673
Abstract: TLQP-21 is a 21-amino acid neuropeptide derived from the VGF precursor protein. TLQP-21 is expressed in the nervous system and neuroendocrine glands, and demonstrates pleiotropic roles including regulating metabolism, nociception and microglial functions. Several possible… read more here.
Keywords: erk signalling; potency; tlqp; tlqp low ... See more keywords
Pharmacological and Biochemical Characterization of TLQP-21 Activation of a Binding Site on CHO Cells
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00167
Abstract: VGF is a propeptide of 617 amino acids expressed throughout the central and the peripheral nervous system. VGF and peptides derived from its processing have been found in dense core vesicles and are released from… read more here.
Keywords: cho cells; pharmacological biochemical; biochemical characterization; binding sites ... See more keywords